2-(3-(phenylthio)prop-1-yn-1-yl)benzaldehyde | 1235340-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-(phenylthio)prop-1-yn-1-yl)benzaldehyde
• CAS: 1235340-56-3
• 化学式: C₁₆H₁₂OS
• 分子量: 252.337
• InChiKey: DAAURJDBZUYFNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-(3-(phenylthio)prop-1-yn-1-yl)benzaldehyde 在 二异丙胺 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 10.0h， 生成 3-benzenesulfonyl-naphthalen-2-ol
  参考文献：
  名称：

  Synthesis of Sulfonyl Arenes via Hydroxy/Amino‐Benzannulation of Sulfonyl Enynals

  摘要：

  An assorted set of sulfonyl arenes such as β‐naphthylamines, β‐naphthols, phenols and naphthalenes could be accessed in a divergent manner by base‐mediated annulation of sulfonyl enynals. The strategy is extended to the synthesis of heterocycles such as carbazole, quinoline and benzothiophene. Benzannulation is demonstrated on derivatives of natural steroids like estrone and cholesterol.

  DOI：

  10.1002/adsc.202301106
• 作为产物：
  描述：

  苯硫酚 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 10.0h， 生成 2-(3-(phenylthio)prop-1-yn-1-yl)benzaldehyde
  参考文献：
  名称：

  Synthesis of Sulfonyl Arenes via Hydroxy/Amino‐Benzannulation of Sulfonyl Enynals

  摘要：

  An assorted set of sulfonyl arenes such as β‐naphthylamines, β‐naphthols, phenols and naphthalenes could be accessed in a divergent manner by base‐mediated annulation of sulfonyl enynals. The strategy is extended to the synthesis of heterocycles such as carbazole, quinoline and benzothiophene. Benzannulation is demonstrated on derivatives of natural steroids like estrone and cholesterol.

  DOI：

  10.1002/adsc.202301106

文献信息

• Sulfur-Assisted Propargyl−Allenyl Isomerizations and Electrocyclizations for the Convenient and Efficient Synthesis of Polyfunctionalized Benzenes and Naphthalenes
  作者：Hongwei Zhou、Yanpeng Xing、Jinzhong Yao、Junhui Chen

  DOI：10.1021/ol101479d

  日期：2010.8.20

  A facile and efficient electrocyclization for the synthesis of polyfunctionalized benzene and naphthalene derivatives was reported. As a result of the ready availability of starting materials and simple operation, this type of reaction has potential utility in organic synthesis.