6-Acetamido-9-acetyl-4-methyl-α-carbolin | 26066-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-Acetamido-9-acetyl-4-methyl-α-carbolin
• 英文别名: N-(9-acetyl-4-methyl-9H-pyrido[2,3-b]indol-6-yl)-acetamide；N-(9-acetyl-4-methylpyrido[2,3-b]indol-6-yl)acetamide
• CAS: 26066-97-7
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.314
• InChiKey: YWQKQYMZDZVBEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Carbazole derivatives and their use as npy5 receptor antagonists
  申请人：Foote Michael Kevin

  公开号：US20050065157A1

  公开（公告）日：2005-03-24

  The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor: wherein: R 1 , R 2 , R 3 and X 1 -X 6 are as defined within or a pharmaceutically acceptable salt, prodrug or solvate thereof, is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.

  使用化合物（I）的制剂制造药物，用于治疗温血动物中由神经肽Y5受体介导的疾病：其中：R1，R2，R3和X1-X6如定义内所述或其药学上可接受的盐，前药或溶剂化物。还描述了化合物（I）的制备的药物组成，方法和过程。
• CARBAZOLE DERIVATIVES AND THEIR USE AS NPY5 RECEPTOR ANTAGONISTS
  申请人：Astrazeneca AB

  公开号：EP1427729A1

  公开（公告）日：2004-06-16
• US7408064B2
  申请人：——

  公开号：US7408064B2

  公开（公告）日：2008-08-05
• [EN] CARBAZOLE DERIVATIVES AND THEIR USE AS NPY5 RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE CARBAZOLE ET LEUR UTILISATION COMME ANTAGONISTES DES RECEPTEURS NPY5
  申请人：ASTRAZENECA AB

  公开号：WO2003022849A1

  公开（公告）日：2003-03-20

  The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor (I), wherein: R1, R2, R3 and X1-X6 are as defined within or a pharmaceutically acceptable salt, prodrug or solvate thereof, is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.