3-Morpholinophenothiazin | 30476-47-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-Morpholinophenothiazin
• 英文别名: 3-morpholin-4-yl-10H-phenothiazine；4-(10H-phenothiazin-3-yl)morpholine
• CAS: 30476-47-2
• 化学式: C₁₆H₁₆N₂OS
• 分子量: 284.382
• InChiKey: PTTXHUSQFDDLLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(氯甲基)-1-甲基哌啶 、 3-Morpholinophenothiazin 在 lithium hexamethyldisilazane 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 0.25h， 生成 4-[10-[(1-Methylpiperidin-3-yl)methyl]phenothiazin-3-yl]morpholine
  参考文献：
  名称：

  Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors

  摘要：

  Analogs of the psychotropic phenothiazines were synthesized and examined as antitubercular agents against Mycobacterium tuberculosis H37Rv. The compounds were subsequently counter-screened for binding to the dopaminergic-receptor subtypes D1, D2, D3 and the serotonergic-receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2C. The most active compounds showed MICs from 2 to 4 mu g/mL and had overall reduced binding to the dopamine and serotonin receptors compared to chlorpromazine and trifluoperazine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.064
• 作为产物：
  描述：

  4-(4-吗啉基)苯胺 在 tris-(dibenzylideneacetone)dipalladium(0) potassium phosphate 、 碘 、 sulfur 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 水 、 甲苯 为溶剂， 反应 20.33h， 生成 3-Morpholinophenothiazin
  参考文献：
  名称：

  Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors

  摘要：

  Analogs of the psychotropic phenothiazines were synthesized and examined as antitubercular agents against Mycobacterium tuberculosis H37Rv. The compounds were subsequently counter-screened for binding to the dopaminergic-receptor subtypes D1, D2, D3 and the serotonergic-receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2C. The most active compounds showed MICs from 2 to 4 mu g/mL and had overall reduced binding to the dopamine and serotonin receptors compared to chlorpromazine and trifluoperazine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.064

文献信息

• Phenothiazynes: preparation of 2- and 3-tertiary aminophenothiazines
  作者：D. H. Jones

  DOI：10.1039/j39710000132

  日期：——

  A possible general route to 2- and 3-tertiary aminophenothiazines is described.

  描述了制备2-和3-叔氨基吩噻嗪的可能的通用途径。
• USE OF BENZENE DERIVATIVES AS CHARGE TRANSFER MEDIATORS
  申请人：NOVO NORDISK A/S

  公开号：EP0552223A1

  公开（公告）日：1993-07-28
• [EN] USE OF BENZENE DERIVATIVES AS CHARGE TRANSFER MEDIATORS
  申请人：——

  公开号：WO1992007263A1

  公开（公告）日：1992-04-30

  [EN] Benzene derivatives having optionally substituted amino or morpholino in the 1 and 4 position, optionally alkyl in the 2, 3 and 6 position and optionally alkyl or nitro in the 5 position or wherein the 1 and 6 substituents together form a heterocyclic ring, can be used as a charge transfer mediator in a biochemical process involving electron transfer between a redox system and an electrode comprising a paste of electrically conductive particles and a pasting material.
  [FR] On peut utiliser des dérivés benzéniques possédant un amino ou morpholino facultativement substitué en position 1 et 4, éventuellement un alcoyle en position 2,3, et 6 et éventuellement un alcoyle ou un nitro en position 5 ou dans lesquels les substituants 1 et 6 forment ensemble un noyau hétérocyclique comme médiateur de transfert de charge dans un procédé biochimique comportant le transfert d'électrons entre un système de redox et une électrode comprenant une pâte de particules électriquement conductrices et un matériau d'empâtage.