tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2- yl(methyl) carbamate | 1268383-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2- yl(methyl) carbamate
• 英文别名: tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate
• CAS: 1268383-14-7
• 化学式: C₂₃H₃₃N₅O₃Si
• 分子量: 455.632
• InChiKey: MKCWVKNQHIOGEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  100.37
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2- yl(methyl) carbamate 在 氨 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 tert-butyl N-[4-amino-5-(benzyloxy)-1,2-dihydro-1-(2-(trimethylsilyl)ethyl)-2- oxopyrimido[4,5-d]pyrimidin-7-yl]-N-methylcarbamate
  参考文献：
  名称：

  Synthesis of a β-glycoside functionalized GΛC motif for self-assembly into rosette nanotubes with predefined length

  摘要：

  Progress toward the synthesis of guanine cytosine (G Lambda C) oligonucleotides for the spontaneous self-assembly of rosette nanotubes (RNTs) with predefined length is described. Highlighted is the synthesis of the beta-glycoside functionalized G Lambda C base along with a new nitrogen protecting group strategy that is compatible with Boc and Bn groups. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.122
• 作为产物：
  描述：

  tert-butyl 4-(benzyloxy)-5-formyl-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl)carbamate 在 吡啶 、 三乙胺 、 三氟乙酸酐 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2- yl(methyl) carbamate
  参考文献：
  名称：

  Synthesis of a β-glycoside functionalized GΛC motif for self-assembly into rosette nanotubes with predefined length

  摘要：

  Progress toward the synthesis of guanine cytosine (G Lambda C) oligonucleotides for the spontaneous self-assembly of rosette nanotubes (RNTs) with predefined length is described. Highlighted is the synthesis of the beta-glycoside functionalized G Lambda C base along with a new nitrogen protecting group strategy that is compatible with Boc and Bn groups. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.122