diethyl 3-(difluoromethyl)-2,4-bis(ethoxycarbonyl)-glutarate | 1314024-59-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 3-(difluoromethyl)-2,4-bis(ethoxycarbonyl)-glutarate
• 英文别名: Tetraethyl 2-(difluoromethyl)propane-1,1,3,3-tetracarboxylate；tetraethyl 2-(difluoromethyl)propane-1,1,3,3-tetracarboxylate
• CAS: 1314024-59-3
• 化学式: C₁₆H₂₄F₂O₈
• 分子量: 382.359
• InChiKey: UBTLOMRZPABJTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  丙二酸二乙酯钠盐 在 水 、 二异丁基氢化铝 、 lithium chloride 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 9.0h， 生成 diethyl 3-(difluoromethyl)-2-(ethoxycarbonyl)glutarate 、 diethyl 3-(difluoromethyl)-2,4-bis(ethoxycarbonyl)-glutarate
  参考文献：
  名称：

  Utilization of perfluoroalkanoate-derived aluminium acetals as the convenient fluorinated aldehyde precursors

  摘要：

  Aluminium acetals from the DIBAL partial reduction of perfluoroalkanoates 1 were successfully employed as the convenient and useful fluorinated aldehyde precursors, and reactions of such intermediates with sodium salts from some beta-dicarbonyl compounds 2 as well as their possible utility as the Michael acceptors after transformation to the corresponding alkylidene malonates 8 were also demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.007

文献信息

• Utilization of perfluoroalkanoate-derived aluminium acetals as the convenient fluorinated aldehyde precursors
  作者：Sumika Aoki、Tomoko Kawasaki-Takasuka、Takashi Yamazaki

  DOI：10.1016/j.tet.2011.05.007

  日期：2011.7

  Aluminium acetals from the DIBAL partial reduction of perfluoroalkanoates 1 were successfully employed as the convenient and useful fluorinated aldehyde precursors, and reactions of such intermediates with sodium salts from some beta-dicarbonyl compounds 2 as well as their possible utility as the Michael acceptors after transformation to the corresponding alkylidene malonates 8 were also demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.