| 1441781-19-6

• CAS: 1441781-19-6
• 化学式: C₁₈H₂₄ClFeN₆PPdS
• 分子量: 585.189
• InChiKey: VAYYMEYZKNBHKV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  、 1,3,5-三氮杂-7-磷杂金刚烷 以 丙酮 为溶剂， 反应 3.0h， 以52%的产率得到
  参考文献：
  名称：

  Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation

  摘要：

  Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes (3-5) were prepared through the cleavage of a chlorido-bridged palladium ferrocenylthiosemicarbazone intermediate (2) using various P-donor ligands. These compounds were screened for antiplasmodial activity against chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, exhibiting biological activity in the low micromolar range. The compounds generally display well-resolved electrochemically reversible one-electron transfer processes for the ferrocenyl group. The half-wave potential for the Fe(II)/Fe(III) couple is electronically influenced by the type of P-donor group through the palladium(II) centre. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2013.04.017