(E)-(4-(2-iodovinyl)phenyl)(methyl)sulfane | 1421606-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(4-(2-iodovinyl)phenyl)(methyl)sulfane
• CAS: 1421606-38-3
• 化学式: C₉H₉IS
• 分子量: 276.141
• InChiKey: HLILDFZXXOYYFI-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-methoxy-2-quinaldamide 、 (E)-(4-(2-iodovinyl)phenyl)(methyl)sulfane 在 copper(I) oxide 、 caesium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 以91%的产率得到(E)-4-methoxy-N-(4-(methylthio)styryl)quinoline-2-carboxamide
  参考文献：
  名称：

  Synthesis of Perspicamide A and Related Diverse Analogues: Their Bioevaluation as Potent Antileishmanial Agents

  摘要：

  The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 246, 24c, 24d, and 241, exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 mu M and a selectivity index (SI) ranging from 9.58 to 53.12, which is improved compared to the standard drug Miltefosine (IC50 12.4 mu M and SI 4.1).

  DOI：

  10.1021/jo3025626
• 作为产物：
  描述：

  4-Methylmercapto-zimtsaeure 在 N-碘代丁二酰亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-(4-(2-iodovinyl)phenyl)(methyl)sulfane
  参考文献：
  名称：

  Synthesis of Perspicamide A and Related Diverse Analogues: Their Bioevaluation as Potent Antileishmanial Agents

  摘要：

  The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 246, 24c, 24d, and 241, exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 mu M and a selectivity index (SI) ranging from 9.58 to 53.12, which is improved compared to the standard drug Miltefosine (IC50 12.4 mu M and SI 4.1).

  DOI：

  10.1021/jo3025626

文献信息

• Rhodium-Catalyzed Deoxygenation and Borylation of Ketones: A Combined Experimental and Theoretical Investigation
  作者：Lei Tao、Xueying Guo、Jie Li、Ruoling Li、Zhenyang Lin、Wanxiang Zhao

  DOI：10.1021/jacs.0c07854

  日期：2020.10.21

  The rhodium-catalyzed deoxygenation and borylation of ketones with B2pin2 have been developed, leading to efficient formation of alkenes, vinylboronates, and vinyldiboronates. These reactions feature mild reaction conditions, a broad substrate scope, and excellent functional-group compatibility. Mechanistic studies support that the ketones initially undergo a Rh-catalyzed deoxygenation to give alkenes

  已经开发了铑催化的酮与 B2pin2 的脱氧和硼酸化，从而有效地形成烯烃、乙烯基硼酸酯和乙烯基二硼酸酯。这些反应的特点是反应条件温和，底物范围广，官能团兼容性好。机理研究支持酮最初经过 Rh 催化脱氧以通过硼烯醇化物中间体得到烯烃，随后 Rh 催化的烯烃脱氢硼化导致乙烯基硼酸酯和二硼化产物的形成，这也得到 DFT 计算的支持。
• Rhodium‐Catalyzed Anti‐Markovnikov Transfer Hydroiodination of Terminal Alkynes**
  作者：Philip Boehm、Niklas Kehl、Bill Morandi

  DOI：10.1002/anie.202214071

  日期：2023.1.23

  We report a shuttle approach for the Rh-catalyzed anti-Markovnikov hydroiodination of terminal alkynes to vinyl iodides. For aliphatic alkynes, a ligand- and substrate-dependent stereodivergence is observable. The vinyl iodides are engaged in a variety of C−C and C−X bond-forming reactions. The method is used to shorten a synthetic sequence to a cis-fatty acid. Deuterium-labeling and stoichiometric

  我们报告了一种用于 Rh 催化的末端炔烃反马尔可夫尼科夫氢碘化为乙烯基碘化物的穿梭方法。对于脂肪族炔烃，可以观察到配体和底物依赖性立体分歧。乙烯基碘化物参与各种 C−C 和 C−X 键形成反应。该方法用于将合成序列缩短为顺式脂肪酸。氘标记和化学计量实验提供了对该机制的深入了解。