2-(2-hydroxybenzoyl)-3-(2,5-dimethoxyphenyl)-4H-furo[3,2-c]chromen-4-one | 1389311-70-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-(2-hydroxybenzoyl)-3-(2,5-dimethoxyphenyl)-4H-furo[3,2-c]chromen-4-one
• 英文别名: 3-(2,5-Dimethoxyphenyl)-2-(2-hydroxybenzoyl)furo[3,2-c]chromen-4-one；3-(2,5-dimethoxyphenyl)-2-(2-hydroxybenzoyl)furo[3,2-c]chromen-4-one
• CAS: 1389311-70-9
• 化学式: C₂₆H₁₈O₇
• 分子量: 442.425
• InChiKey: MSKMAMMHOHSVST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  95.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 dipotassium peroxodisulfate 、 碘 、 sodium carbonate 作用下， 以 PEG300 为溶剂， 反应 10.0h， 以47%的产率得到2-(2-hydroxybenzoyl)-3-(2,5-dimethoxyphenyl)-4H-furo[3,2-c]chromen-4-one
  参考文献：
  名称：

  Synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component reaction in poly(ethylene glycol)

  摘要：

  An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2 equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I-2 and K2S2O8 in the presence of Na2CO3 was used as an oxidative reagent. The structure of the furo[3,2-c]coumarins was established by X-ray single crystal structure analysis. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.05.112

文献信息

• Synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component reaction in poly(ethylene glycol)
  作者：Zeinab Zareai、Mehdi Khoobi、Ali Ramazani、Alireza Foroumadi、Ali Souldozi、Katarzyna Ślepokura、Tadeusz Lis、Abbas Shafiee

  DOI：10.1016/j.tet.2012.05.112

  日期：2012.8

  An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2 equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I-2 and K2S2O8 in the presence of Na2CO3 was used as an oxidative reagent. The structure of the furo[3,2-c]coumarins was established by X-ray single crystal structure analysis. (c) 2012 Elsevier Ltd. All rights reserved.