Opt.-inakt. <2-Carboxy-cyclopentyl>-methyl-keton | 5732-76-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: Opt.-inakt. <2-Carboxy-cyclopentyl>-methyl-keton
• 英文别名: 2-acetylcyclopentanoate；2-Acetylcyclopentane-1-carboxylic acid
• CAS: 5732-76-3
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: WTWMVYYFHWFNIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] GRANZYME B INHIBITOR FORMULATIONS AND METHODS FOR THE TREATMENT OF BURNS<br/>[FR] FORMULATIONS INHIBITRICES DE GRANZYME B ET MÉTHODES DE TRAITEMENT DE BRÛLURES
  申请人：VIDA THERAPEUTICS INC

  公开号：WO2017132771A1

  公开（公告）日：2017-08-10

  Formulations for treating burns and burn wound healing comprising a Granzyme B inhibitor and a pharmaceutically acceptable carrier, and methods for treating burns and for burn wound healing using the formulations.

  治疗烧伤和烧伤愈合的配方包括一种Granzyme B抑制剂和一种药用可接受载体，以及使用这些配方进行治疗烧伤和烧伤愈合的方法。
• Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239838A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  提供了包括公式I或其药学上可接受的盐或组合物的补体因子D抑制剂的化合物、使用方法和制备方法。本文所描述的抑制剂靶向因子D并在替代补体途径的早期和关键点上抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所述的因子D抑制剂能够减少补体过度激活，该过度激活已与某些自身免疫性、炎症性和神经退行性疾病以及缺血再灌注损伤和癌症有关。
• Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0130633A2

  公开（公告）日：1985-01-09

  Intermediates of Formula where R, X1, X2, X3 and X4 have the meanings mentioned in the description, for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives.

  式的中间体 其中 R、X1、X2、X3 和 X4 具有说明中提到的含义，用于制备 1-(苯基)-1-羟基-2-氨基-3-氟丙烷衍生物。
• Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0678506A2

  公开（公告）日：1995-10-25

  A process for preparing a D-threo compound of the formula wherein R, and R1 have the meanings shown in the description, via protection of both the secondary hydroxy and the amino group of a corresponding D-threo 1-(phenyl)-2-amino-1,3-propanediol, fluorination of the protected compound and treatment of the thus obtained compound to afford a D-threo compound of the formula (II).

  一种制备式 D-硫代化合物的工艺 其中 R 和 R1 具有说明中所示的含义，通过保护相应 D-硫代 1-(苯基)-2-氨基-1,3-丙二醇的仲羟基和氨基，将保护后的化合物氟化，并处理由此得到的化合物，得到式 (II) 的 D-硫代化合物。
• Catalytic component based on vanadium and its use in the preparation of EP (D) M
  申请人：ENICHEM S.p.A.

  公开号：EP0790227A1

  公开（公告）日：1997-08-20

  Catalytic component for the (co)polymerization of alpha-olefins consisting of the compound having the general formula VL3, wherein V is trivalent vanadium and L is a ligand selected from those having general formula (I): wherein R is selected from H and C1-C20 monofunctional hydrocarbyl radicals; n is an integer between 2 and 13 excluding 4 and 5.

  用于α-烯烃（共）聚合的催化组分，由通式为 VL3 的化合物组成，其中 V 为三价钒，L 为选自通式(I)的配体： 其中 R 选自 H 和 C1-C20 单官能团烃基；n 是介于 2 和 13 之间的整数，不包括 4 和 5。