methyl 3-(cyclopropylmethoxy)-4-formylbenzoate | 1548871-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(cyclopropylmethoxy)-4-formylbenzoate
• 英文别名: Methyl 3-(cyclopropylmethoxy)-4-formylbenzoate
• CAS: 1548871-69-7
• 化学式: C₁₃H₁₄O₄
• 分子量: 234.252
• InChiKey: PPCWEDFQZMONBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3-(cyclopropylmethoxy)-4-formylbenzoate 在 吡啶 、 水 、 N,N'-羰基二咪唑 、 lithium hydroxide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 74.5h， 生成 (Z)-methyl 3-(cyclopropylmethoxy)-4-((methoxyimino) methyl)benzoate
  参考文献：
  名称：

  1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

  摘要：

  本文描述的化合物（I）的公式是磷酸二酯酶4（PDE4）酶的抑制剂，可用于预防和/或治疗由气道阻塞特征的过敏病状态或呼吸道疾病。

  公开号：

  US20140155391A1
• 作为产物：
  描述：

  4-甲酰-3-羟基苯甲酸 在 氯化亚砜 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 methyl 3-(cyclopropylmethoxy)-4-formylbenzoate
  参考文献：
  名称：

  1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

  摘要：

  本文描述的化合物（I）的公式是磷酸二酯酶4（PDE4）酶的抑制剂，可用于预防和/或治疗由气道阻塞特征的过敏病状态或呼吸道疾病。

  公开号：

  US20140155391A1

文献信息

• Foaming composition with wettability modifying and corrosion inhibitory properties for high temperature and ultra-high salinity
  申请人：Instituto Mexicano Del Petróleo

  公开号：EP2740781A1

  公开（公告）日：2014-06-11

  The present invention relates to obtaining and using foaming compositions with wettability-modifying and corrosion inhibitory properties that control the channeling of fluids in naturally fractured carbonate reservoirs, favorably alter the rock wettability in crude oil enhanced recovery processes and control uniform corrosion problems occurring in production rigs under high temperature and ultra-high salinity conditions; by means of the synergistic effect resulting from the supramolecular interaction of alkyl amido propyl hydroxysultaines or alkyl hydroxysultaines with sodium alkyl hydroxysulfonates and sodium alkenyl sulfonates (1). The foaming compositions with wettability-modifying and corrosion inhibitory properties are characterized for being tolerant to high concentrations of divalent ions such as calcium, magnesium, strontium and barium and for the fact that for their application in the reservoir, seawater and/or congenital water characteristic of the reservoir may be used as means of transportation.

  本发明涉及获得和使用具有润湿性改良和腐蚀抑制特性的发泡组合物，该组合物可控制天然裂缝碳酸盐储层中的流体通道，有利地改变原油提高采收率过程中的岩石润湿性，并控制高温和超高盐度条件下生产钻机中出现的均匀腐蚀问题；通过烷基酰胺丙基羟基磺烷或烷基羟基磺烷与烷基羟基磺酸钠和烯基磺酸钠的超分子相互作用产生的协同效应（1）。具有润湿改性和缓蚀特性的发泡组合物的特点是能够耐受高浓度的钙、镁、锶和钡等二价离子，而且在储层中应用时，可以使用海水和/或储层特有的先天性水作为运输工具。
• Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases
  作者：Elisabetta Armani、Gabriele Amari、Andrea Rizzi、Renato De Fanti、Eleonora Ghidini、Carmelida Capaldi、Laura Carzaniga、Paola Caruso、Matilde Guala、Ilaria Peretto、Elena La Porta、Pier T. Bolzoni、Fabrizio Facchinetti、Chiara Carnini、Nadia Moretto、Riccardo Patacchini、Franco Bassani、Valentina Cenacchi、Roberta Volta、Francesco Amadei、Silvia Capacchi、Maurizio Delcanale、Paola Puccini、Silvia Catinella、Maurizio Civelli、Gino Villetti

  DOI：10.1021/jm401549m

  日期：2014.2.13

  The first steps in the selection process of a new anti-inflammatory drug for the inhaled treatment of asthma and chronic obstructive pulmonary disease are herein described. A series of novel ester derivatives of 1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-di-chloropyriclin-4-yl) ethanol have been synthesized and evaluated for inhibitory activity toward cAMP-specific phosphodiesterase-4 (PDE4). In particular, esters of variously substituted benzoic acids were extensively explored, and structural modification of the alcoholic and benzoic moieties were performed to maximize the inhibitory potency. Several compounds with high activity in cell-free and cell-based assays were obtained. Through the evaluation of opportune in vitro ADME properties, a potential candidate suitable for inhaled administration in respiratory diseases was identified and tested in an in vivo model of pulmonary inflammation, proving its efficacy.
• FOAMING COMPOSITION WITH WETTABILITY MODIFYING AND CORROSION INHIBITORY PROPERTIES FOR HIGH TEMPERATURE AND ULTRA-HIGH SALINITY
  申请人：Instituto Mexicano Del Petróleo

  公开号：EP2740781B1

  公开（公告）日：2015-12-30
• COMPOSITIONS VÉTÉRINAIRES NON RINCÉES
  申请人：Ceva Santé Animale

  公开号：EP4065096A1

  公开（公告）日：2022-10-05
• US9469804B2
  申请人：——

  公开号：US9469804B2

  公开（公告）日：2016-10-18