methyl t-butoxycarbonyloxy-2'-nitrophenylglycinate | 239077-32-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl t-butoxycarbonyloxy-2'-nitrophenylglycinate
• 英文别名: Methyl 2-((tert-butoxycarbonyl)amino)-2-(2-nitrophenyl)acetate；methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(2-nitrophenyl)acetate
• CAS: 239077-32-8
• 化学式: C₁₄H₁₈N₂O₆
• 分子量: 310.307
• InChiKey: NUGIAJUXVQMDLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl t-butoxycarbonyloxy-2'-nitrophenylglycinate 在 吡啶 、 sodium hydroxide 、 sodium tetrahydroborate 、 caesium carbonate 作用下， 生成 [2-Mercapto-1-(2-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  A photoremovable ligation auxiliary for use in polypeptide synthesis

  摘要：

  A photoremovable auxiliary for use in peptide synthesis via the native chemical ligation method is described. A 2-mercapto-1-(2-nitrophenyl)ethylamine (Mnpe-amine) moiety was attached to the N-terminus of a peptide via the periodate oxidation of a seryl peptide. The resulting peptide was then ligated to a peptide thioester, and UV (365 nm) irradiation resulted in the removal of the auxiliary from the peptide. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01463-1
• 作为产物：
  描述：

  ((R)-2-Hydroxy-1-phenyl-ethylamino)-(2-nitro-phenyl)-acetic acid methyl ester 在 lead(IV) acetate 、 盐酸 、 三乙胺 作用下， 生成 methyl t-butoxycarbonyloxy-2'-nitrophenylglycinate
  参考文献：
  名称：

  Synthesis and protein kinase C binding activity of benzolactam-V7

  摘要：

  Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKC alpha. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00207-3