2'-ethoxybiphenyl-2-amine | 142505-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-ethoxybiphenyl-2-amine
• 英文别名: 2-amino-2'-ethoxybiphenyl；4'-ethoxy-3,5-biphenyl-4-ylamine；2'-Ethoxy-biphenyl-2-ylamine；2-(2-ethoxyphenyl)aniline
• CAS: 142505-62-2
• 化学式: C₁₄H₁₅NO
• 分子量: 213.279
• InChiKey: PHPIOZKKCCRTJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-adamantyl-5-tert-butyl-2-hydroxybenzaldehyde 、 2'-ethoxybiphenyl-2-amine 在 Amberlyst 15(H) 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以52%的产率得到2-(1-Adamantyl)-4-tert-butyl-6-[[2-(2-ethoxyphenyl)phenyl]iminomethyl]phenol
  参考文献：
  名称：

  JP5769444

  摘要：

  公开号：
• 作为产物：
  描述：

  2'-硝基-2-联苯醇 在 palladium on activated charcoal 氢氧化钾 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.5h， 生成 2'-ethoxybiphenyl-2-amine
  参考文献：
  名称：

  Cylisation reactions of 2-substituted biphenyl-2′-yldiazonium salts leading to O-alkyldibenzofuranium and S-alkyl-dibenzothiophenium salts: modified meerwein reagents

  摘要：

  The preparation of 2-amino-2'-methoxybiphenyl and 2-amino-2-thiomethoxybiphenyl and analogues and their transformation into diazonium salts and hence into dibenzofuranium and dibenzothiophenium salts is described together with their use as alkylating agents.

  DOI：

  10.1016/s0040-4020(01)88480-5

文献信息

• Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20150231142A1

  公开（公告）日：2015-08-20

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及含有上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
  申请人：Van Goor Fredrick F.

  公开号：US20110098311A1

  公开（公告）日：2011-04-28

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及包含上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Sheth Urvi

  公开号：US20120309758A1

  公开（公告）日：2012-12-06

  The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

  本发明涉及调节ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节蛋白，以及相关的组合物和方法。本发明还涉及使用这些调节剂治疗ABC转运蛋白介导的疾病的方法。
• Liquid crystal compounds, liquid crystal medium and liquid crystal display
  申请人：——

  公开号：US20020142108A1

  公开（公告）日：2002-10-03

  The instant invention relates to liquid crystal media comprising a strongly dielectrically positive component A, preferably comprising isothiocyanate compounds, most preferably compounds of formula I, as given in the text, and a further dielectrically positive component B, preferably comprising terminally polar substituted bi- or terphenyl compounds, most preferably comprising compounds of formula II, as given in the text, further to novel isothiocyanato compounds as well as to liquid crystal displays comprising these media, in particular to PDLC display and most particular to holographic PDLC displays. The instant invention further relates to compounds of formula I 1 wherein the parameters are as as specified in the text.

  本发明涉及液晶介质，包括强介电正性组分A，优选包括异硫氰酸酯化合物，最优选为公式I所示的化合物，以及进一步的介电正性组分B，优选包括末端极性取代的双苯或三苯基化合物，最优选包括公式II所示的化合物。此外，本发明还涉及新型的异硫氰酸酯化合物，以及包括这些介质的液晶显示器，特别是PDLC显示器，最特别是全息PDLC显示器。本发明还涉及公式I1中参数如文本所述的化合物。
• Modulators of ATP-binding cassette transporters
  申请人：Hadida-Ruah Sara

  公开号：US20060074075A1

  公开（公告）日：2006-04-06

  The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

  本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子及其组合物和使用这些调节剂治疗ABC转运蛋白介导的疾病的方法。