tert-butyl (2S)-6-azido-2-(((benzyloxy)carbonyl)amino)-5-(((2R,3R,4R,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-3-hydroxytetrahydro-2H-pyran-2-yl)oxy)hexanoate | 1005413-38-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tert-butyl (2S)-6-azido-2-(((benzyloxy)carbonyl)amino)-5-(((2R,3R,4R,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-3-hydroxytetrahydro-2H-pyran-2-yl)oxy)hexanoate
• CAS: 1005413-38-6
• 化学式: C₄₅H₅₄N₄O₁₀
• 分子量: 810.945
• InChiKey: ZOYUKUJSOHZCSI-MIQXJXEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.57
• 重原子数：
  59.0
• 可旋转键数：
  21.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  179.77
• 氢给体数：
  2.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (2S)-6-azido-2-(((benzyloxy)carbonyl)amino)-5-(((2R,3R,4R,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-3-hydroxytetrahydro-2H-pyran-2-yl)oxy)hexanoate 、 2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl trichloroacetimidate 在 3 A molecular sieve 、 叔丁基二甲硅基三氟甲磺酸酯 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以76%的产率得到tert-butyl (2S)-6-azido-2-benzyloxycarbonylamino-5-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyloxy)-(1->2)-(3,4,6-tri-O-benzyl-β-D-galactopyranosyloxy)]hexanoate
  参考文献：
  名称：

  A simple strategy for the synthesis of the glycosylated collagen biomarkers α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl

  摘要：

  A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.10.037