2-methyl-1-butyl methanesulfonate | 113806-17-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-methyl-1-butyl methanesulfonate
• 英文别名: 2-methylbutyl mesylate；2-Methylbutyl methanesulfonate
• CAS: 113806-17-0
• 化学式: C₆H₁₄O₃S
• 分子量: 166.241
• InChiKey: BANBAERELZGEAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  253.7±9.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-1-butyl methanesulfonate 在 sodium iodide 作用下， 以 丙酮 为溶剂， 生成 1-碘-2-甲基丁烷
  参考文献：
  名称：

  莫舍尔硫酸盐：用于确定S N 2底物对映体过量的试剂

  摘要：

  Mosher的硫代酸2-甲氧基-2-三氟甲基苯基乙酸硫代酸的外消旋和（S）-对映异构体与质子海绵[1,8-双（二​​甲基氨基）萘]形成空气稳定的盐。这些盐是强大的亲核试剂反应，该干净（S Ñ在CDCl 2反转）3与光学活性烷基卤化物范围从非活化的烷基溴化物和碘化物，以苄基溴化物反应性。硫酯产物的非对映体过量（de）表示起始烷基卤化物的对映体过量（ee）。

  DOI：

  10.1016/j.tetlet.2010.03.041

文献信息

• 6-Arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors
  申请人：Hendrix Martin

  公开号：US20070105881A1

  公开（公告）日：2007-05-10

  The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.

  该发明涉及新型的式(I)的6-芳基氨基-5-氰基-4-嘧啶酮、其制备方法以及用于制备用于提高意识、注意力、学习能力和/或记忆力的药物的用途。所述化合物(I)表现出PDE9抑制剂的活性。
• PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN
  申请人：Conway Brian G

  公开号：US20090247743A1

  公开（公告）日：2009-10-01

  Disclosed are materials and methods for preparing optically active β-amino acids of Formula 1, which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.

  本发明涉及制备配方1的光学活性β-氨基酸的材料和方法，该配方1结合到钙通道的α2δ亚单位。
• Additive Components for Liquid Crystalline Materials
  申请人：Cherkaoui Mohammed Zoubair

  公开号：US20070257230A1

  公开（公告）日：2007-11-08

  The present invention relates to mesogenic, cross-linkable mixtures comprising (i) a cross-linkable liquid crystalline host compound comprising at least one cross-linkable liquid crystalline compound, and (ii) at least one chiral or achiral rod shaped additive component, wherein said additive component has a rigid core and comprises at least two fused or linked, optionally substituted, non-aromatic, aromatic, carbocyclic or heterocyclic groups, and also comprises at least one optionally substituted alkyl residue, and at least one polymerizable group and wherein the additive component has a transition temperature to the isotropic state of 40° C. or lower. The invention also relates to the novel chiral or achiral rod-shaped additive compounds used for the preparation of these mixtures, to mixtures according to the invention in form of an elastomer, polymer gel, polymer network or polymer film, to polymer networks and liquid crystalline polymer films prepared from these mixtures and to optical or electrooptical components comprising polymer networks and liquid crystalline polymer films prepared from such mixtures. Further, the invention relates to the use of the chiral or achiral rod shaped compounds as components of a cross-linkable liquid crystalline mixture in the production of orientated liquid crystalline polymers, to liquid crystalline mixtures comprising these compounds, to liquid crystalline polymers and liquid crystalline polymer networks prepared from such liquid crystalline mixtures, and to liquid crystalline devices comprising these compounds.

  本发明涉及到一种向列相交联混合物，包括（i）至少包含一种可交联向列相化合物的可交联向列相宿主化合物，和（ii）至少一种手性或无手性的棒状添加剂组分，其中该添加剂组分具有刚性的核心，包括至少两个融合或连接的、可选地取代的非芳香族、芳香族、碳环族或杂环族基团，同时包括至少一个可选地取代的烷基残基和至少一个可聚合基团，且该添加剂组分具有向等向态转变的转变温度为40℃或更低。本发明还涉及用于制备这些混合物的新手性或无手性棒状添加剂化合物，以及以弹性体、聚合物凝胶、聚合物网络或聚合物膜形式的本发明的混合物、从这些混合物制备的聚合物网络和向列相聚合物膜、以及包含从这些混合物制备的聚合物网络和向列相聚合物膜的光学或电光组件。此外，本发明还涉及将手性或无手性棒状化合物用作可交联向列相混合物的组分，用于生产定向向列相聚合物，液晶混合物包括这些化合物，从这些液晶混合物制备的液晶聚合物和液晶聚合物网络，以及包含这些化合物的液晶装置的使用。
• Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
  申请人：Evans Claire Margaret

  公开号：US20070141684A1

  公开（公告）日：2007-06-21

  Disclosed are materials and methods for preparing optically active γ-amino acids of Formula 1, which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.

  本发明公开了一种制备光学活性γ-氨基酸的材料和方法，其化合物符合公式1，可以与钙通道的α2δ亚单位结合。
• 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS
  申请人：HENDRIX Martin

  公开号：US20090111838A1

  公开（公告）日：2009-04-30

  The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.

  该发明涉及化学式(I)的新型6-芳胺基-5-氰基-4-嘧啶酮的制备方法，以及用于制备改善意识、注意力、学习能力和/或记忆保持力的药物的用途。化合物(I)表现出PDE9抑制剂的活性。