(R)-N-(2-chloro-6-fluorobenzyl)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | 1179355-75-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-N-(2-chloro-6-fluorobenzyl)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
• 英文别名: tert-butyl (4R)-4-[(2-chloro-6-fluorophenyl)methylcarbamoyl]-5,5-dimethyl-1,3-thiazolidine-3-carboxylate
• CAS: 1179355-75-9
• 化学式: C₁₈H₂₄ClFN₂O₃S
• 分子量: 402.918
• InChiKey: ROBFSCPORPQDFW-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-N-(2-chloro-6-fluorobenzyl)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 在 盐酸 、 苯甲醚 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S₂′ Pocket

  摘要：

  A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P-2' moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared to the o-methylbenzyl moiety in clinical candidate I (KNI-764, also known as JE-2147, AG-1776, or SM-319777). Introduction of all anilinic amino group to 2 (KNI-727) improved water-solubility and anti-HIV-1 activity, X-ray crystallographic analysis of 13k (KNI-1689) with a beta-methallyl group kit P-2' position revealed hydrophobic interactions with Ala28, Ile84, kind Ile50' similar to that of 1. The presence of an additional methyl group on the allyl group in compound 13k significantly increased anti-HIV activity over 1 while providing a rational drug design for structural minimization and improving membrane permeability.

  DOI：

  10.1021/jm9005115
• 作为产物：
  描述：

  2-氯-6-氟苄胺 、 (R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到(R)-N-(2-chloro-6-fluorobenzyl)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
  参考文献：
  名称：

  Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S₂′ Pocket

  摘要：

  A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P-2' moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared to the o-methylbenzyl moiety in clinical candidate I (KNI-764, also known as JE-2147, AG-1776, or SM-319777). Introduction of all anilinic amino group to 2 (KNI-727) improved water-solubility and anti-HIV-1 activity, X-ray crystallographic analysis of 13k (KNI-1689) with a beta-methallyl group kit P-2' position revealed hydrophobic interactions with Ala28, Ile84, kind Ile50' similar to that of 1. The presence of an additional methyl group on the allyl group in compound 13k significantly increased anti-HIV activity over 1 while providing a rational drug design for structural minimization and improving membrane permeability.

  DOI：

  10.1021/jm9005115

文献信息

• Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S₂′ Pocket
  作者：Koushi Hidaka、Tooru Kimura、Hamdy M. Abdel-Rahman、Jeffrey-Tri Nguyen、Keith F. McDaniel、William E. Kohlbrenner、Akhteruzzaman Molla、Motoyasu Adachi、Taro Tamada、Ryota Kuroki、Noriko Katsuki、Yoshiaki Tanaka、Hikaru Matsumoto、Jun Wang、Yoshio Hayashi、Dale J. Kempf、Yoshiaki Kiso

  DOI：10.1021/jm9005115

  日期：2009.12.10

  A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P-2' moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared to the o-methylbenzyl moiety in clinical candidate I (KNI-764, also known as JE-2147, AG-1776, or SM-319777). Introduction of all anilinic amino group to 2 (KNI-727) improved water-solubility and anti-HIV-1 activity, X-ray crystallographic analysis of 13k (KNI-1689) with a beta-methallyl group kit P-2' position revealed hydrophobic interactions with Ala28, Ile84, kind Ile50' similar to that of 1. The presence of an additional methyl group on the allyl group in compound 13k significantly increased anti-HIV activity over 1 while providing a rational drug design for structural minimization and improving membrane permeability.