2'-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yl)-5'-oxo-7',7'-dimethyl-6',8'-dihydrospiro-[2-oxo-1H-indol-3,4'-chromen] | 1219602-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2'-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yl)-5'-oxo-7',7'-dimethyl-6',8'-dihydrospiro-[2-oxo-1H-indol-3,4'-chromen]
• 英文别名: 7',7'-dimethyl-2'-(6-oxo-3,4-diphenyl-1H-pyridazin-5-yl)spiro[1H-indole-3,4'-6,8-dihydrochromene]-2,5'-dione
• CAS: 1219602-27-3
• 化学式: C₃₄H₂₇N₃O₄
• 分子量: 541.606
• InChiKey: HJBYPZKDNMNRRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  41
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  96.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yloxoethylidene)-1,3-dihydro-2H-indol-2-one 、 5,5-二甲基-1,3-环己二酮 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以71%的产率得到2'-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yl)-5'-oxo-7',7'-dimethyl-6',8'-dihydrospiro-[2-oxo-1H-indol-3,4'-chromen]
  参考文献：
  名称：

  Synthesis of Some New Pyridazinylspirohetarylindoles and Hetarylpyridazine Derivatives

  摘要：

  Condensation of 4-acetyl-5,6-diphenylpyridazine-3(2H)-one (1) with 1H-indol-2,3-dione afforded the biheterocyclic enone 2. Interaction of 2 with some bifunctional nitrogen nucleophiles and dimedone yielded some novel pyridazinyl spirohetarylindoles 3-6. The reaction of 3-chloropyridazine derivative 7 with some heterocyclic compounds having vicinal amino and cyano groups gave hetarylaminopyridazines 9 and 13. Treatment of acetylpyridazinone I with arylidenecyanoacetate and arylidenemalononitrile afforded pyridylpyridazines 16 and 19, respectively. The effect of some active methylene compounds and thioacetamide on biheterocyclic enone 22 was also studied.

  DOI：

  10.3987/com-09-11845

文献信息

• Synthesis of Some New Pyridazinylspirohetarylindoles and Hetarylpyridazine Derivatives
  作者：Yassin Gabr、Mohamed Abdel-Megid、Mohamed Abdel-Hamid Awas、Naser Mohamed Abdel-Fatah

  DOI：10.3987/com-09-11845

  日期：——

  Condensation of 4-acetyl-5,6-diphenylpyridazine-3(2H)-one (1) with 1H-indol-2,3-dione afforded the biheterocyclic enone 2. Interaction of 2 with some bifunctional nitrogen nucleophiles and dimedone yielded some novel pyridazinyl spirohetarylindoles 3-6. The reaction of 3-chloropyridazine derivative 7 with some heterocyclic compounds having vicinal amino and cyano groups gave hetarylaminopyridazines 9 and 13. Treatment of acetylpyridazinone I with arylidenecyanoacetate and arylidenemalononitrile afforded pyridylpyridazines 16 and 19, respectively. The effect of some active methylene compounds and thioacetamide on biheterocyclic enone 22 was also studied.