γ-bromo-β-(2-thenyl)butyric acid methyl ester | 240403-88-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: γ-bromo-β-(2-thenyl)butyric acid methyl ester
• 英文别名: methyl γ-bromo-β-thenylbutyrate；Methyl 3-(bromomethyl)-4-thiophen-2-ylbutanoate
• CAS: 240403-88-7
• 化学式: C₁₀H₁₃BrO₂S
• 分子量: 277.182
• InChiKey: FKSSULBHAJYFFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  γ-bromo-β-(2-thenyl)butyric acid methyl ester 在 盐酸 、 PPA 、 potassium carbonate 、 potassium iodide 作用下， 以 甲醇 为溶剂， 反应 41.0h， 生成 1-<(4-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)-methyl>piperazine
  参考文献：
  名称：

  构象受限的丁苯酮与多巴胺能（D（2））和5-羟色胺能（5-HT（2A），5-HT（2C））的亲和力：合成，药理学，3D-QSAR和（氨基烷基）苯并和-的分子建模硫杂环丁烷作为非典型抗精神病药。

  摘要：

  一系列新的构象受限的丁苯酮（2-（氨基乙基）-和3-（氨基甲基）噻吩基或苯并环烷酮，带有（6-氟苯并恶唑基）哌啶，（对氟苯甲酰基）哌啶，（邻甲氧基苯基）哌嗪或线性丁苯酮片段）制备并通过对多巴胺受体（D（1），D（2））和血清素受体（5-HT（2A），5-HT（2C））的亲和力进行体外测定，评估为非典型抗精神病药抗精神病药潜力的体内测定和诱发锥体外系副作用的风险。效能和选择性主要取决于连接至环烷酮结构的胺片段。作为一组，具有苯并异恶唑基片段的化合物具有最高的5-HT（2A）活性，其次是苯甲酰基哌啶衍生物。一般来说，α-取代的环烷酮衍生物比相应的β-取代的同类物更具活性。CoMFA（比较分子场分析）和对接研究表明，静电，空间和亲脂性的决定因素5-HT（2A）和D（2）亲和力和5-HT（2A）/ D（2）选择性。N-[（4-oxo-4H-5，6-dihydrocyclopenta [b] thiophene-5-yl）ethyl]

  DOI：

  10.1021/jm981094e
• 作为产物：
  描述：

  重氮甲烷 、 γ-bromo-β-(2-thenyl)butyric acid 以 乙醚 为溶剂， 生成 γ-bromo-β-(2-thenyl)butyric acid methyl ester
  参考文献：
  名称：

  构象受限的丁苯酮与多巴胺能（D（2））和5-羟色胺能（5-HT（2A），5-HT（2C））的亲和力：合成，药理学，3D-QSAR和（氨基烷基）苯并和-的分子建模硫杂环丁烷作为非典型抗精神病药。

  摘要：

  一系列新的构象受限的丁苯酮（2-（氨基乙基）-和3-（氨基甲基）噻吩基或苯并环烷酮，带有（6-氟苯并恶唑基）哌啶，（对氟苯甲酰基）哌啶，（邻甲氧基苯基）哌嗪或线性丁苯酮片段）制备并通过对多巴胺受体（D（1），D（2））和血清素受体（5-HT（2A），5-HT（2C））的亲和力进行体外测定，评估为非典型抗精神病药抗精神病药潜力的体内测定和诱发锥体外系副作用的风险。效能和选择性主要取决于连接至环烷酮结构的胺片段。作为一组，具有苯并异恶唑基片段的化合物具有最高的5-HT（2A）活性，其次是苯甲酰基哌啶衍生物。一般来说，α-取代的环烷酮衍生物比相应的β-取代的同类物更具活性。CoMFA（比较分子场分析）和对接研究表明，静电，空间和亲脂性的决定因素5-HT（2A）和D（2）亲和力和5-HT（2A）/ D（2）选择性。N-[（4-oxo-4H-5，6-dihydrocyclopenta [b] thiophene-5-yl）ethyl]

  DOI：

  10.1021/jm981094e

文献信息

• New Serotonin 5-HT_2A, 5-HT_2B, and 5-HT_2C Receptor Antagonists:  Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo and Heterocycloalkanones
  作者：José Brea、Jordi Rodrigo、Antonio Carrieri、Ferran Sanz、M. Isabel Cadavid、María J. Enguix、María Villazón、Guadalupe Mengod、Yolanda Caro、Christian F. Masaguer、Enrique Raviña、Nuria B. Centeno、Angelo Carotti、M. Isabel Loza

  DOI：10.1021/jm011014y

  日期：2002.1.1

  A series of 52 conformationally constrained butyrophenones have been synthesized and pharmacologically tested as antagonists at 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors, useful for dissecting the role of each 5-HT2 subtype in pathophysiology. These compounds were also a consistent set for the identification of structural features relevant to receptor recognition and subtype discrimination. Six compounds were found highly active (pK(1) > 8.76) and selective at the 5-HT2A receptor vs 5-HT2B and/or 5-HT2C receptors. Piperidine fragments confer high affinity at the 5-HT2A receptor subtype, with benzofuranone- and thiotetralonepiperidine as the most selective derivatives over 5-HT2C and 5-HT2B receptors, respectively; K-1 2A/2C and/or K-B 2A/2B ratios greater than 100 were obtained. Compounds showing a more pronounced selectivity at 5-HT2A/5-HT2C than at 5-HT2A/5-HT2B bear 6-fluorobenzisoxazolyl- and p-fluorobenzoylpiperidine moieties containing one methylene bridging the basic piperidine, to the alkanone moiety. An ethylene bridge between the alkanone and the amino moieties led to ligands with higher affinities for the 5-HT2B receptor. Significant selectivity at the 5-HT2B receptor vs 5-HT2C was observed with 1-1[(1-oxo-1,2,3,4-tetrahydro-3-naphthyl)methyl-4-[3-(p-fluorobenzoyl)propyl]piperazine (more than 100-fold higher). Although piperidine fragments also confer higher affinity at 5-HT2C receptors, only piperazine-containing ligands were selective over 5-HT2A. Moderate selectivity was observed at 5-HT2C vs 5-HT2B (10-fold) with some compounds bearing a 4-[3-(6-fluorobenzisoxazolyl)]piperidine moiety in its structure. Molecular determinants for antagonists acting at 5-HT2A receptors were identified by 3D-QSAR (GRID-GOLPE) studies. Docking simulations at 5-HT2A and 5-HT2C receptors suggest a binding site for the studied type of antagonists (between transmembrane helices 2, 3, and 7) different to that of the natural agonist serotonin (between 3, 5, and 6).
• Conformationally Constrained Butyrophenones with Mixed Dopaminergic (D₂) and Serotoninergic (5-HT_2A, 5-HT_2C) Affinities:  Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo- and -thienocycloalkanones as Putative Atypical Antipsychotics
  作者：Enrique Raviña、Jesús Negreira、José Cid、Christian F. Masaguer、Elizabeth Rosa、M. Emilia Rivas、José A. Fontenla、M. Isabel Loza、Helena Tristán、M. Isabel Cadavid、Ferran Sanz、Estrella Lozoya、Angelo Carotti、Antonio Carrieri

  DOI：10.1021/jm981094e

  日期：1999.7.1

  A series of novel conformationally restricted butyrophenones (2-(aminoethyl)- and 3-(aminomethyl)thieno- or benzocycloalkanones bearing (6-fluorobenzisoxazolyl)piperidine, (p-fluorobenzoyl)piperidine, (o-methoxyphenyl)piperazine, or linear butyrophenone fragments) were prepared and evaluated as atypical antipsychotic agents by in vitro assays of affinity for dopamine receptors (D(1), D(2)) and serotonin

  一系列新的构象受限的丁苯酮（2-（氨基乙基）-和3-（氨基甲基）噻吩基或苯并环烷酮，带有（6-氟苯并恶唑基）哌啶，（对氟苯甲酰基）哌啶，（邻甲氧基苯基）哌嗪或线性丁苯酮片段）制备并通过对多巴胺受体（D（1），D（2））和血清素受体（5-HT（2A），5-HT（2C））的亲和力进行体外测定，评估为非典型抗精神病药抗精神病药潜力的体内测定和诱发锥体外系副作用的风险。效能和选择性主要取决于连接至环烷酮结构的胺片段。作为一组，具有苯并异恶唑基片段的化合物具有最高的5-HT（2A）活性，其次是苯甲酰基哌啶衍生物。一般来说，α-取代的环烷酮衍生物比相应的β-取代的同类物更具活性。CoMFA（比较分子场分析）和对接研究表明，静电，空间和亲脂性的决定因素5-HT（2A）和D（2）亲和力和5-HT（2A）/ D（2）选择性。N-[（4-oxo-4H-5，6-dihydrocyclopenta [b] thiophene-5-yl）ethyl]