磷钨酸水合物 | 12501-23-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 中文名称: 磷钨酸水合物
• 中文别名: 橙黄G6；钨磷酸水合物；12-钨磷酸水合物；磷钨酸；钨磷酸
• 英文名称: Tungstophosphoric acid
• 英文别名: phosphoric acid;trioxotungsten;hydrate
• CAS: 12501-23-4
• 化学式: H5O41PW12
• 分子量: 2898.1
• InChiKey: AVFBYUADVDVJQL-UHFFFAOYSA-N

物化性质

• 熔点：
  ~95 °C(lit.)
• 沸点：
  107.9℃[at 101 325 Pa]
• 密度：
  3.88[at 20℃]
• 暴露限值：
  ACGIH: TWA 3 mg/m3NIOSH: TWA 5 mg/m3; STEL 10 mg/m3
• 稳定性/保质期：
  在常温常压下，该物质是稳定的。应避免光照、明火和高温环境。 它极易溶于水（约85%质量分数），同时也易溶于其他供电子有机溶剂，如丙酮、DMF等。在水中，磷钨酸会完全解离。通过X射线技术和中子衍射法研究了三种磷钨酸的水合物（H3PW12O40·nH2O，其中n分别为6、21和29）。仅六水合物中的水分子可以定位，并发现质子以平面H5O+2离子形式存在。在水中，PW12的稳定酸度范围有限，在pH为1.5～5时会迅速转变为缺位的PW11阴离子。

计算性质

• 辛醇/水分配系数(LogP)：
  -6.06
• 重原子数：
  54
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  693
• 氢给体数：
  4
• 氢受体数：
  41

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 危险品标志：
  C
• 危险类别码：
  R34
• 危险品运输编号：
  UN 3260
• WGK Germany：
  2,3
• RTECS号：
  TH5650000
• 海关编码：
  2811 19 80,2811199090
• 危险类别：
  8
• 安全说明：
  S24/25,S26,S36/37/39,S45

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : Phosphotungstic acid hydrate
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 12501-23-4
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin corrosion (Category 1B), H314
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
C Corrosive R34
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard none
Statements
Other hazards - none

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SECTION 3: Composition/information on ingredients
Substances
Synonyms : Tungstophosphoric acid
Formula : H3O40PW12 · xH2O
Molecular Weight : 2.880,05 g/mol
CAS-No. : 12501-23-4
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Phosphotungstic acid hydrate
CAS-No. 12501-23-4 Skin Corr. 1B; H314 <= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
Phosphotungstic acid hydrate
CAS-No. 12501-23-4 C, R34 <= 100 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Oxides of phosphorus, Tungsten oxide
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone [phone], test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
anticipated use by our customers. It should not be construed as offering an approval for any
specific use scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: crystalline
Colour: white
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 95 °C - lit.
point
f) Initial boiling point and no data available
boiling range
g) Flash point not applicable
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents, Strong bases
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
Cough, Shortness of breath, Headache, Nausea, Vomiting

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SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

---

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
UN number
ADR/RID: 3260 IMDG: 3260 IATA: 3260
UN proper shipping name
ADR/RID: CORROSIVE SOLID, ACIDIC, INORGANIC, N.O.S. (Phosphotungstic acid hydrate)
IMDG: CORROSIVE SOLID, ACIDIC, INORGANIC, N.O.S. (Phosphotungstic acid hydrate)
IATA: Corrosive solid, acidic, inorganic, n.o.s. (Phosphotungstic acid hydrate)
Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

---

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SECTION 15 - REGULATORY INFORMATION
N/A

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

该试剂主要用于生化试剂及色谱分析试剂。它可以用于检测各种生物碱、含氮碱、酚类物质、蛋白质、蛋白胨、氨基酸、脲酸、脲、血液和碳水化合物等。

用途

此外，它还可作为生物染色剂使用。具体应用包括：

1. 有机合成反应的催化剂，在国内主要取代环境污染严重的液体酸类，如硫酸、氢氟酸、三氯化铝等；在国外则是一种新型的固体酸催化剂，并受到许多合成领域的关注。
2. 生化试剂及色谱分析试剂：广泛用于药物分离、鉴定以及化学毒物的毒理学研究、法医学鉴定和生物材料分析中。例如，在阿托品、氨基比林、奎宁、普鲁卡因和可卡因等物质的检测中，常使用磷钨酸乙醇溶液进行薄层色谱法分析；通过生成磷钨酸来进行相关分析。

生产方法

生产磷钨酸的方法简便易行。可以用酸化钨酸盐与磷酸盐的混合溶液制得，也可以直接将粉状白钨酸溶于磷酸中。

反应信息

• 作为产物：
  描述：

  磷酸 、 Hexaazanium;hydroxy-[(oxido(dioxo)tungstenio)oxy-dioxotungstenio]oxy-dioxotungsten;hydroxy-[[(oxido(dioxo)tungstenio)oxy-dioxotungstenio]oxy-dioxotungstenio]oxy-dioxotungsten;tungsten;trihydroxide;hydrate 在 Ti 作用下， 以 水 为溶剂， 生成 磷钨酸水合物
  参考文献：
  名称：

  Process for manufacturing acrolein/acrylic acid

  摘要：

  本发明涉及在富含丙烯醛的流体中选择性消除丙酮醛，以生产含有低量丙酮醛和/或丙酸和/或丙烯腈和/或甲基巯基丙醛的丙烯醛和/或丙烯酸和/或丙烯腈。本发明的一个目的是提供一种制造丙烯醛的方法，包括在与至少钼组成的催化剂接触的丙烯醛富集流体中选择性消除丙酮醛的步骤。本发明的另一个目的是提供一种从甘油制造丙烯酸的方法，包括在与至少钼组成的催化剂接触的丙烯醛富集流体中选择性消除丙酮醛的步骤。

  公开号：

  US09296676B2
• 作为试剂：
  描述：

  R(+)-alpha-甲基苄胺 、 (E)-3-(2-naphthyl)-2-propenal 、 硼氢化钠 在 磷钨酸水合物 碳酸氢钠 、 水 、 Brine 、 magnesium sulfate 、 crude product 、 silica gel 、 EtOAc hexanes 作用下， 以 EtOAc hexanes 、 甲醇 为溶剂， 反应 0.92h， 以to afford 52 mg of Compound 33的产率得到(R,E)-3-(naphthalen-2-yl)-N-(1-phenylethyl)prop-2-en-1-amine
  参考文献：
  名称：

  FENDILINE DERIVATIVES AND METHODS OF USE THEREOF

  摘要：

  本文披露了芬地林的新衍生物，包括以下化合物：其中变量在此定义。还提供了包含这些衍生物化合物的制药组合物、工具箱和制造物品。还提供了有用于制备这些衍生物的方法和中间体，以及使用这些衍生物的方法，例如用于抑制K-Ras质膜定位的方法和组合物，包括用于治疗癌症的组合物。

  公开号：

  US20150344407A1

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME
  申请人：Kutose Koichi

  公开号：US20130023664A1

  公开（公告）日：2013-01-24

  There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R 1 and R 2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R 3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R 4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)

  提供了一种含氮杂环化合物，例如由公式（1）表示的取代氨基吡啶-N-氧化物化合物，可用作农药等合成中间体；以及生产含氮杂环化合物的方法。（在公式（1）中，R1和R2分别表示氢原子或未取代或取代的烷基基团；R3表示氢原子、未取代或取代的烷基羰基基团或类似物；R4表示未取代或取代的烷基羰基基团、未取代或取代的芳基羰基基团或类似物；A表示羟基、硫醇基或类似物；m表示1至4的任意整数之一；k表示0至3的任意整数之一；且k+m≤4。）
• Catalyst For Reducing Selectively Saturated Aldehyde And A Process For Preparing The Catalyst
  申请人：Okumura Kimito

  公开号：US20140024861A1

  公开（公告）日：2014-01-23

  [Problem] Catalyst for use in selective reduction of propionaldehyde in acrolein and/or acrylic acid and/or acrylonitrile containing propionaldehyde and/or propionic acid and/or propionitrile at low concentration. In particular, a novel catalyst for selectively reducing propionaldehyde from acrolein containing the propionaldehyde. [Solution] Catalyst for use in selective reduction of propionaldehyde in acrolein containing the propionaldehyde, characterized in that the catalyst contains Mo as an indispensable component, and at least one element selected from a group comprising P, Si, W, Ti, Zr, V, Nb, Ta, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, In, Tl, Sn, Ag, As, Ge, B, Bi, La, Ba, Sb, Te, Ce, Pb, Mg, K, Rb, Cs and Al.

  [问题] 用于选择性还原含有丙醛和/或丙酸和/或丙腈的丙醛的丙烯醛和/或丙烯酸和/或丙腈的催化剂，其中丙醛和/或丙酸和/或丙腈的浓度较低。特别地，用于从含有丙醛的丙烯醛中选择性还原丙醛的新型催化剂。 [解决方案] 用于选择性还原含有丙醛的丙烯醛中的丙醛的催化剂，其特征在于催化剂包含Mo作为不可或缺的组分，并且至少包含一种从包括P、Si、W、Ti、Zr、V、Nb、Ta、Cr、Mn、Fe、Co、Ni、Cu、Zn、Ga、In、Tl、Sn、Ag、As、Ge、B、Bi、La、Ba、Sb、Te、Ce、Pb、Mg、K、Rb、Cs和Al的元素组中选择的元素。
• Nitrogen-containing heterocyclic compound and method for producing same
  申请人：Kutose Koichi

  公开号：US08703959B2

  公开（公告）日：2014-04-22

  There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R1 and R2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)

  提供了一种含氮杂环化合物，如式（1）所表示的取代氨基吡啶-N-氧化物化合物，它可用作农药等合成中间体；以及一种生产含氮杂环化合物的方法。（在式（1）中，R1和R2分别表示氢原子或未取代或取代的烷基；R3表示氢原子，未取代或取代的烷基羰基基团或类似物；R4表示未取代或取代的烷基羰基基团，未取代或取代的芳基羰基基团或类似物；A表示羟基，硫醇基或类似物；m表示1到4中的任意整数之一；k表示0到3中的任意整数之一；且k+m≤4。)
• PROCESS FOR MANUFACTURING ACROLEIN/ACRYLIC ACID
  申请人：Devaux Jean-Francois

  公开号：US20130324758A1

  公开（公告）日：2013-12-05

  The present invention relates to the selective elimination of propanal in acrolein-rich streams to produce acrolein and/or acrylic acid and/or acrylonitrile and/or methylmercaptopropionaldehyde containing low amount of propanal and/or propionic acid and/or propionitrile. One subject of the present invention is a process for manufacturing acrolein comprising a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum. Another subject of the present invention is a process for manufacturing acrylic acid from glycerol including a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum.

  本发明涉及在丙烯醛富含流中选择性去除丙酮醛，以生产含有低量丙酮醛和/或丙酸和/或丙腈的丙烯醛和/或丙烯酸和/或丙烯腈和/或甲基巯基丙醛。本发明的一个目的是提供一种制造丙烯醛的方法，其中包括与至少含钼的催化剂接触的丙烯醛富含流中选择性去除丙酮醛的步骤。本发明的另一个目的是提供一种从甘油制造丙烯酸的方法，其中包括与至少含钼的催化剂接触的丙烯醛富含流中选择性去除丙酮醛的步骤。
• Process for manufacturing acrolein/acrylic acid
  申请人：Devaux Jean-Francois

  公开号：US09296676B2

  公开（公告）日：2016-03-29

  The present invention relates to the selective elimination of propanal in acrolein-rich streams to produce acrolein and/or acrylic acid and/or acrylonitrile and/or methylmercaptopropionaldehyde containing low amount of propanal and/or propionic acid and/or propionitrile. One subject of the present invention is a process for manufacturing acrolein comprising a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum. Another subject of the present invention is a process for manufacturing acrylic acid from glycerol including a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum.

  本发明涉及在富含丙烯醛的流体中选择性消除丙酮醛，以生产含有低量丙酮醛和/或丙酸和/或丙烯腈和/或甲基巯基丙醛的丙烯醛和/或丙烯酸和/或丙烯腈。本发明的一个目的是提供一种制造丙烯醛的方法，包括在与至少钼组成的催化剂接触的丙烯醛富集流体中选择性消除丙酮醛的步骤。本发明的另一个目的是提供一种从甘油制造丙烯酸的方法，包括在与至少钼组成的催化剂接触的丙烯醛富集流体中选择性消除丙酮醛的步骤。

表征谱图