1-methyl-N-(2-(2-(trifluoromethyl)phenyl)-1H-indol-6-yl)-1H-1,2,4-triazole-5-carboxamide | 2242913-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-N-(2-(2-(trifluoromethyl)phenyl)-1H-indol-6-yl)-1H-1,2,4-triazole-5-carboxamide
• 英文别名: 2-methyl-N-[2-[2-(trifluoromethyl)phenyl]-1H-indol-6-yl]-1,2,4-triazole-3-carboxamide
• CAS: 2242913-34-2
• 化学式: C₁₉H₁₄F₃N₅O
• 分子量: 385.348
• InChiKey: SIVLPTHXGYYTPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] ARYL HYDROCARBON RECEPTOR (AHR) MODULATOR COMPOUNDS<br/>[FR] COMPOSÉS MODULATEURS DU RÉCEPTEUR DES HYDROCARBURES ARYLE (AHR)
  申请人：PHENEX PHARMACEUTICALS AG

  公开号：WO2018153893A1

  公开（公告）日：2018-08-30

  The present invention relates to 6-amido-1H-indol-2-yl compounds which can act as aryl hydrocarbon receptor (AhR) modulators and, in particular, as AhR antagonists. The invention further relates to the use of the compounds for the treatment and/or prophylaxis of diseases and/or conditions through binding of said aryl hydrocarbon receptor by said compounds.

  本发明涉及6-酰胺-1H-吲哚-2-基化合物，可作为芳香族羟基化酶（AhR）调节剂，特别是作为AhR拮抗剂。本发明还涉及利用该化合物通过结合所述AhR，治疗和/或预防疾病和/或症状的用途。
• ARYL HYDROCARBON RECEPTOR (AHR) MODULATOR COMPOUNDS
  申请人：PHENEX PHARMACEUTICALS AG

  公开号：US20200031805A1

  公开（公告）日：2020-01-30

  The present invention relates to 6-amido-1H-indol-2-yl compounds which can act as aryl hydrocarbon receptor (AhR) modulators and, in particular, as AhR antagonists. The invention further relates to the use of the compounds for the treatment and/or prophylaxis of diseases and/or conditions through binding of said aryl hydrocarbon receptor by said compounds.