1-cyclohexyl-3,4-diethylpyrrolidine-2,5-dione | 1189104-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-cyclohexyl-3,4-diethylpyrrolidine-2,5-dione
• CAS: 1189104-22-0
• 化学式: C₁₄H₂₃NO₂
• 分子量: 237.342
• InChiKey: UWFUYSLZHWWIPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-己炔 、 一氧化碳 、 环己胺 在 十二羰基三铁 作用下， 以 四氢呋喃 为溶剂， 120.0 ℃ 、2.0 MPa 条件下， 以56%的产率得到1-cyclohexyl-3,4-diethylpyrrolidine-2,5-dione
  参考文献：
  名称：

  铁催化的羰基化：琥珀酰亚胺的选择性和高效合成

  摘要：

  已经开发了一种方便的一锅法合成各种取代的琥珀酰亚胺。通过从市售的胺（或氨）和炔烃开始，在[Fe（CO）5 ]或[Fe 3（CO）12 ]的存在下选择性地获得了一系列有趣的琥珀酰亚胺（参见方案； R'= H，烷基，芳基； R''，R'''=烷基，芳基）。

  DOI：

  10.1002/anie.200902078

文献信息

• Improved Synthesis Of Succinimides And Quaternary Ammonium Ions For Use In Making Molecular Sieves
  申请人：EXXONMOBIL CHEMICAL PATENTS INC.

  公开号：US20150329487A1

  公开（公告）日：2015-11-19

  The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

  本发明涉及琥珀酰亚胺的合成，特别涉及一种琥珀酰亚胺化合物的合成方法，包括以下步骤：在铁催化剂的存在下，将炔烃与一氧化碳和氨或胺反应，在胺液相中和/或无醚溶剂的情况下进行反应。琥珀酰亚胺可以还原为季铵阳离子，可用作分子筛合成中的结构定向剂。
• Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US10035762B2

  公开（公告）日：2018-07-31

  The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

  本发明涉及琥珀酰亚胺的合成，特别是琥珀酰亚胺化合物的合成方法，包括在铁催化剂存在下使炔烃与一氧化碳和氨或胺反应的步骤，其中反应在胺液相中和/或在没有醚溶剂的情况下进行。琥珀酰亚胺可还原成季铵阳离子，在合成分子筛时可用作结构引导剂。
• Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides
  作者：Huizhen Liu、Genevieve P. S. Lau、Paul J. Dyson

  DOI：10.1021/jo502412v

  日期：2015.1.2

  Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.
• Synthesis of Succinimides and Quaternary Ammonium Ions for Use in Making Molecular Sieves
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20180305309A1

  公开（公告）日：2018-10-25

  The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.
• [EN] IMPROVED SYNTHESIS OF SUCCINIMIDES AND QUATERNARY AMMONIUM IONS FOR USE IN MAKING MOLECULAR SIEVES<br/>[FR] SYNTHÈSE AMÉLIORÉE DE SUCCINIMIDES ET D'IONS AMMONIUM QUATERNAIRES DESTINÉE À ÊTRE UTILISÉE DANS LA FABRICATION DE TAMIS MOLÉCULAIRES
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2014100218A1

  公开（公告）日：2014-06-26

  The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.