N1,N3-bis(4-chloro-2-pyrimidinyl)-1,3-propanediamine | 1161880-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N1,N3-bis(4-chloro-2-pyrimidinyl)-1,3-propanediamine
• CAS: 1161880-00-7
• 化学式: C₁₁H₁₂Cl₂N₆
• 分子量: 299.162
• InChiKey: CMADGGGQVZRMGM-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2,4-二氯嘧啶 、 1,3-丙二胺 在 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以29%的产率得到N1,N3-bis(2-chloro-4-pyrimidinyl)-1,3-propanediamine
  参考文献：
  名称：

  Amination of 2-chloro-and 2,4-dichloropyrimidines by polyamines

  摘要：

  A study was carried out on the amination of 2-chloro-and 2,4-dichloropyrimidines by linear polyamines and oxadiamines under catalytic and noncatalytic conditions. The reaction of excess polyamine with 2-chloropyrimidine gives the corresponding 2-aminopyrimidines, while the reaction of polyamines with excess of 2-chloropyrimidine gives di-, tri-, and tetraarylated derivatives. The reaction of 2,4-dichloropyrimidine with diamines was studied with different ratios of the starting reagents. The ratios of the products of substitution at pyrimidine C-2 and C-4 were found.

  DOI：

  10.1007/s10593-008-0165-7