7-(2-(triisopropylsilyloxy)benzyloxy)-2H-chromen-2-one | 1145732-60-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(2-(triisopropylsilyloxy)benzyloxy)-2H-chromen-2-one
• 英文别名: 7-[[2-Tri(propan-2-yl)silyloxyphenyl]methoxy]chromen-2-one；7-[[2-tri(propan-2-yl)silyloxyphenyl]methoxy]chromen-2-one
• CAS: 1145732-60-0
• 化学式: C₂₅H₃₂O₄Si
• 分子量: 424.612
• InChiKey: GOSYWCNJWUBLSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.93
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(2-(triisopropylsilyloxy)benzyloxy)-2H-chromen-2-one 在 四丁基氟化铵 作用下， 以 二氯甲烷 为溶剂， 生成 Tri-isopropylfluorsilan 、 Umbelliferone
  参考文献：
  名称：

  Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

  摘要：

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

  DOI：

  10.1021/ol900433g
• 作为产物：
  描述：

  (2-(iodomethyl)phenoxy)triisopropylsilane 、 7-hydroxycoumarin potassium salt 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以45%的产率得到7-(2-(triisopropylsilyloxy)benzyloxy)-2H-chromen-2-one
  参考文献：
  名称：

  Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

  摘要：

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

  DOI：

  10.1021/ol900433g

文献信息

• Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?
  作者：Ho Yong Lee、Xuan Jiang、Dongwhan Lee

  DOI：10.1021/ol900433g

  日期：2009.5.21

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.