3-(2-hydroxy-ethyl)-1H-pyrimidine-2,4-dione | 700-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(2-hydroxy-ethyl)-1H-pyrimidine-2,4-dione
• 英文别名: 3-(2-hydroxyethyl)-2,4(1H,3H)-pyrimidinedione；3-(2-Hydroxy-aethyl)-uracil；3-(2-Hydroxyaethyl)uracil；3-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione；3-(2-hydroxyethyl)-1H-pyrimidine-2,4-dione
• CAS: 700-03-8
• 化学式: C₆H₈N₂O₃
• 分子量: 156.141
• InChiKey: ANAGMCJHWBDYME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氯仿 、 3-(2-hydroxy-ethyl)-1H-pyrimidine-2,4-dione 在 氯化亚砜 作用下， 生成 3-(2-chloroethyl)-2,4(1H,3H)-pyrimidinedione
  参考文献：
  名称：

  N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives

  摘要：

  具有抗组胺作用的新型N-(4-哌啶基)双环2-咪唑胺衍生物，这些化合物在治疗过敏性疾病中非常有用。

  公开号：

  US04588722A1

文献信息

• Pentopyranosylnucleoside, its preparation and use
  申请人：Nanogen Recognomics GmbH

  公开号：US20040198966A1

  公开（公告）日：2004-10-07

  The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) 1 their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.

  本发明涉及一种式（I）或式（II）的五糖基嘌呤核苷，以及它们的制备和用于制备治疗、诊断和/或电子组件的用途。
• Pentopyranosyl nucleic acid arrays, and uses thereof
  申请人：Aventis Research and Technologies GmbH & Co. KG

  公开号：US20030039997A1

  公开（公告）日：2003-02-27

  The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) 1 their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.

  本发明涉及公式（I）或公式（II）的五糖基嘌呤核苷，以及它们的制备和用于生产治疗、诊断和/或电子组件。
• Linker nucleoside, its preparation and use
  申请人：Miculka Christian

  公开号：US20050004356A1

  公开（公告）日：2005-01-06

  The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.

  本发明涉及连接核苷酸、其制备和用于将生物分子与寡核苷酸共价键合的应用，特别是用于p-RNA寡核苷酸的共价键合。
• Process for the preparation of a pentopyranosyl conjugate
  申请人：Miculka Christian

  公开号：US20050053945A1

  公开（公告）日：2005-03-10

  The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.

  本发明涉及公式(I)或公式(II)的五碳杂环核苷的制备及其用于制备治疗、诊断和/或电子组件。
• PROCESS FOR PREPARING A PENTOPYRANOSYL NUCLEIC ACID CONJUGATE
  申请人：Miculka Christian

  公开号：US20090221793A1

  公开（公告）日：2009-09-03

  The invention relates to a process for preparing a conjugate that includes a pentopyranosyl nucleic acid and a biomolecule. The process includes the steps of providing a pentopyranosyl nucleic acid having at least two pentopyranosyl nucleotide subunits that are covalently linked between carbon 4 and carbon 2 of their respective pentopyranosyl rings. The pentopyranosyl nucleic acid also has an electrophilic reactive group. A biomolecule having a nucleophilic reactive group is also provided. The electrophilic reactive group of the pentopyranosyl nucleic acid and the nucleophilic reactive group of the biomolecule are reacted to form a covalent bond.

  本发明涉及一种制备包括五碳糖核酸和生物分子的共轭物的方法。该方法包括以下步骤：提供一种具有至少两个五碳糖核苷酸亚基的五碳糖核酸，这些亚基在它们各自的五碳糖环的碳4和碳2之间共价键结合。五碳糖核酸还具有一个亲电反应基团。同时提供一种具有亲核反应基团的生物分子。将五碳糖核酸的亲电反应基团和生物分子的亲核反应基团反应以形成共价键。