5-Chloro-3-[(3-trifluoromethyl-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid | 688748-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-Chloro-3-[(3-trifluoromethyl-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid
• 英文别名: 5-chloro-3-[2-oxo-2-[3-(trifluoromethyl)anilino]ethyl]-1H-indole-2-carboxylic acid
• CAS: 688748-27-8
• 化学式: C₁₈H₁₂ClF₃N₂O₃
• 分子量: 396.753
• InChiKey: FBICUAGIUYZJJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS
  申请人：Nardi Antonio

  公开号：US20100099732A1

  公开（公告）日：2010-04-22

  This invention relates to pharmaceutical compositions comprising phenylcarbamoyl-methyl-indole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.