6-chloro-N-(pyridin-2-yl)pyrazin-2-amine | 642459-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-chloro-N-(pyridin-2-yl)pyrazin-2-amine
• 英文别名: (6-Chloro-pyrazin-2-yl)-pyridin-2-yl-amine；6-Chloro-N-2-pyridinyl-2-pyrazinamine；6-chloro-N-pyridin-2-ylpyrazin-2-amine
• CAS: 642459-38-9
• 化学式: C₉H₇ClN₄
• 分子量: 206.634
• InChiKey: LEWAJTDRWOUGHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基-4-甲基吡啶 、 6-chloro-N-(pyridin-2-yl)pyrazin-2-amine 在 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 sodium t-butanolate 作用下， 以 苯 为溶剂， 反应 72.0h， 以65%的产率得到N2-(4-methylpyridin-2-yl)-N6-(pyridin-2-yl)pyrazine-2,6-diamine
  参考文献：
  名称：

  通过配体设计控制结构和磁性相互作用：从铁磁到反铁磁耦合的一维配合物

  摘要：

  合成了四种不对称的吡嗪和/或 4-甲基吡啶调节的 N,N'-双(α-吡啶基)-2,6-二氨基吡啶配体 (PMN5) 并研究了它们的一维铜 (II) 配合物。当吡嗪是末端环时，配体表现出面内和面外配位模式，并形成一维锯齿状链聚合物。通过桥接吡嗪环的轨道正交重叠导致铁磁相互作用。中环吡嗪调节配体产生直接的一维化合物并具有反铁磁耦合。化合物的 EPR 光谱显示出明显的 Cu-N 键共价键。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008）

  DOI：

  10.1002/ejic.200700881
• 作为产物：
  描述：

  2-氨基吡啶 、 2,6-二氯吡嗪 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 生成 6-chloro-N-(pyridin-2-yl)pyrazin-2-amine
  参考文献：
  名称：

  Polycyclic pyrazines as potassium ion channel modulators

  摘要：

  本发明提供了一类多环吡嗪，可作为钾离子通道调节剂。该发明的调节剂可用于治疗和诊断方法。

  公开号：

  US20050239800A1

文献信息

• POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS
  申请人：Icagen, Inc.

  公开号：EP1742935A1

  公开（公告）日：2007-01-17
• US7642354B2
  申请人：——

  公开号：US7642354B2

  公开（公告）日：2010-01-05
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：ASTEX TECHNOLOGY LTD

  公开号：WO2004004730A2

  公开（公告）日：2004-01-15

  The invention provides a compound of the general formula (I) wherein R1 is selected from hydrogen, cycloalkyl and cycloalkenyl having 3 to 7 ring members; phenyl-C1-4 alkyl or a group R4-A-CH2-, R2 is selected from aryl and heteroaryl having five to twelve ring members; cycloalkyl and cycloalkenyl having 3 to 7 ring members; a group (CR6R7)pE-R8, or R1 and R2 together with the nitrogen atom to which they are attached form a heterocyclic group having 5 to 10 ring members; R3 is a substituent selected from halogen, CN, N-linked monocyclic nitrogen-containing heterocyclic groups having from 3 to 7 ring members and containing up to three heteroatoms; and a group Ra-Rb. The substituents R4-R, Ra and Rb are defined in claim 1. The compounds have activity as inhibitors of cyclin dependent kinases and are useful in the treatment of disease states and conditions, such as proliferative diseases, mediated by cyclin dependent kinases.
• [EN] POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS<br/>[FR] PYRAZINES POLYCYCLIQUES TENANT LIEU DE MODULATEURS DU CANAL IONIQUE DU POTASSIUM
  申请人：ICAGEN INC

  公开号：WO2005121126A1

  公开（公告）日：2005-12-22

  The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is formula II (II); W2 is -CH=, -NH-, -N=, -S-, or -O-; Z1 is formula III (III) or formula IV (IV); Z2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH2-, or -NR5-; s and t are independently integers from 1 to 4; R1, R2A, R2B and R3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R5 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R1 is optionally different; wherein if t is greater than on, then each R3 is optionally different; wherein two R1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.
• Polycyclic pyrazines as potassium ion channel modulators
  申请人：Wang Xiaodong

  公开号：US20050239800A1

  公开（公告）日：2005-10-27

  The present invention provides a genus of polycyclic pyrazines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环吡嗪，可作为钾离子通道调节剂。该发明的调节剂可用于治疗和诊断方法。