1-(4-vinylphenyl)pyrrolidine | 1373368-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(4-vinylphenyl)pyrrolidine
• 英文别名: 1-(4-Ethenylphenyl)pyrrolidine
• CAS: 1373368-72-9
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: KLDKKSTXSKAFBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-vinylphenyl)pyrrolidine 在 1,3-双(二苯基膦)丙烷 、 四丁基溴化铵 、 palladium diacetate 、 potassium carbonate 、 原甲酸三乙酯 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (E)-2-(1,3-dioxan-2-yl)-6-fluoro-4-(4-(pyrrolidin-1-yl)styryl)phenol
  参考文献：
  名称：

  [EN] COMPOUNDS AS MODULATORS OF TLR2 SIGNALING
  [FR] COMPOSÉS UTILISÉS EN TANT QUE MODULATEURS DE SIGNALISATION TLR2

  摘要：

  本公开涉及化合物、包含这种化合物的药物组合物，以及利用这些化合物进行治疗方法或用于治疗与炎症信号传导过程相关的炎症性疾病和某些神经系统疾病的药物。这些神经系统疾病与炎症信号传导过程有关，包括但不限于蛋白质错折。

  公开号：

  WO2019191189A1
• 作为产物：
  描述：

  4-(N-pyrrolidino)acetophenone tosylhydrazone 在 dimesitylmagnesium 、 lithium chloride 、 重水 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 1-(4-vinylphenyl)pyrrolidine 、 α-deuterio-1-(4-vinylphenyl)pyrrolidine
  参考文献：
  名称：

  Modified Shapiro Reactions with Bismesitylmagnesium As an Efficient Base Reagent

  摘要：

  Bismesitylmagnesium has been shown to successfully mediate the Shapiro reaction. A range of tosylhydrazones has been subjected to the developed system, which furnishes exceptionally high incorporation of the introduced electrophiles and good yields of the functionalized styrenes. At conveniently accessible temperatures and with a comparably small excess of base reagent, this protocol offers an efficient alternative to the lithium-mediated process. Importantly, 1.05 equiv of Welnreb amides are sufficient to obtain aryl enones in good yields.

  DOI：

  10.1021/ol300652k

文献信息

• Novel piperidine derivative
  申请人：Ban Hitoshi

  公开号：US20070078120A1

  公开（公告）日：2007-04-05

  The invention provides a compound of the following formula (1): wherein m, n, and p are independently an integer of 0-4, provided 3≦m+n≦8; X is nitrogen atom or a group of the formula: C—R 15 ; Y is a substituted or unsubstituted aromatic group, etc.; R 15 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and Z is hydrogen atom, cyano group, etc., or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which exhibits an action for enhancing LDL receptor expression, and is useful as a medicament for treating hyperlipidemia, atherosclerosis, etc.

  本发明提供了以下式(1)的化合物：其中m，n和p分别是0-4的整数，满足3≦m+n≦8；X是氮原子或式：C—R15的基团；Y是取代或未取代的芳香基团等；R15，R1，R2，R3，R4，R5，R6和R7是氢原子，取代或未取代的烷基等；Z是氢原子，氰基等，或其前药，或其药学上可接受的盐，具有增强LDL受体表达的作用，并且可用作治疗高脂血症，动脉粥样硬化等药物。
• CONJUGATED DIENE POLYMER PRODUCTION METHOD, AND CONJUGATED DIENE POLYMER COMPOSITION PRODUCTION METHOD
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150005440A1

  公开（公告）日：2015-01-01

  A method for producing a conjugated diene-based polymer is provided, in which compounds of formulas (2) and (3) and a conjugated diene compound are polymerized using a compound of formula (1), and then a compound containing a nitrogen atom and/or a silicon atom is reacted with an active end of the polymer formed via the polymerization, R 11 represents a hydrocarbylene group, R 12 and R 13 each represent an optionally substituted hydrocarbyl group or a trihydrocarbylsilyl group, or R 12 is bonded to R 3 and the group in which R 12 is bonded to R 13 represents a hydrocarbylene group optionally having a nitrogen and/or oxygen atom, —Si(R 14 ) 2 —(CH 2 ) x —Si(R 14 ) 2 —, or —Si(R 15 ) 2 —(CH 2 ) y − , and M represents an alkali metal atom, E 2 -A 2 (2) E 3 -A 3 (3) E 2 and E 3 each represent a hydrocarbyl group having a polymerizable carbon-carbon double bond, A 2 represents a substituted amino group or a nitrogen-containing heterocyclic group, and A 3 represents a substituted silyl group.

  提供一种制备基于共轭二烯的聚合物的方法，其中使用式(1)的化合物聚合式(2)和(3)的化合物以及共轭二烯化合物，然后使用含有氮原子和/或硅原子的化合物与通过聚合形成的聚合物的活性末端反应。其中，R11代表烃基烷基，R12和R13分别代表可选取代的烃基或三烷基硅基，或者R12与R3结合，R12与R13结合的基团可选地具有氮和/或氧原子，-Si(R14)2-(CH2)x-Si(R14)2-，或-Si(R15)2-(CH2)y-，M代表碱金属原子，E2-A2(2)E3-A3(3)中，E2和E3分别代表具有可聚合碳-碳双键的烃基，A2代表取代的氨基或含氮杂环基团，A3代表取代的硅基。
• New phthalide derivatives, process for preparing the same and recording system utilizing the same as colourless chromogenic material
  申请人：KANZAKI PAPER MANUFACTURING CO., LTD

  公开号：EP0127203A1

  公开（公告）日：1984-12-05

  New phthalide derivatives useful as colourless chromogenic material have the general formula: wherein R, is hydrogen or one to four substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, nitro and amino group represented by the general formula R2 is hydrogen or lower alkyl; each R3, R4, R5, R., R7 and R9 is hydrogen, lower alkyl, benzyl, halogen substituted benzyl, phenyl, or lower alkyl or loweralkoxy substituted phenyl, orboth ofR. and R4, R5 and R. or R. and R. together with the adjacent nitrogen may form a cyclic polymethylene amino group represented by the general formula a, a is an integer of 4 to 6; R. is hydrogen or one to two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, nitro and cyclic polymethylene amino group represented by the general formula a, a is an integer of 4 to 6; and each X and Y is hydrogen, lower alkyl or lower alkoxy.

  可用作无色致色材料的新邻苯二甲酸酯衍生物具有以下通式 其中 R 是氢或一至四个取代基，这些取代基可从由卤素、低级烷基、低级烷氧基、硝基和氨基组成的组中选出，通式为 R2为氢或低级烷基；R3、R4、R5、R.、R7 和 R9 各为氢、低级烷基、苄基、卤素取代的苄、苯基或低级烷基或低级烷氧基取代的苯基，或 R.和 R4、R5 和 R.或 R.和 R.与相邻的氮一起可形成由通式表示的环状多亚甲基氨基基团。 a, a 为 4-6 的整数；R. 为氢或一至两个取代基，这些取代基可从卤素、低级烷基、低级烷氧基、硝基和通式所代表的环状聚亚甲基氨基所组成的组中选出。 a，a 为 4-6 的整数；X 和 Y 分别为氢、低级烷基或低级烷氧基。
• Divinyl compounds and chromogenic recording material prepared by use thereof
  申请人：YAMADA CHEMICAL CO., LTD.

  公开号：EP0242169A2

  公开（公告）日：1987-10-21

  Divinyl compounds represented by the formula (I): wherein A represents X¹ represents an alkyl group, an alkoxy group, an alkoxy-­alkoxy group, an aryloxy group, a cycloalkoxy group, a haloalkoxy group, an alkenyloxy group, an aralkyloxy group or a halogen atom; X² represents a halogen atom; X³ represents an alkyl group of not more than 8 carbon atoms, an alkoxy group of not more than 8 carbon atoms or a halogen atom; R¹ represents a heterocyclic ring having a nitrogen atom; R² and R³ each represents an alkyl group, an alkoxyalkyl group or a haloalkyl group; and m and n each represents 0, l, 2 or 3; wherein each X¹ or each X³ is the same or different when n or m respectively is 2 or 3 and each X² is the same or different; are chromogenic agents useful for recording materials such as pressure- and heat-­sensitive papers.

  由式(I)代表的二乙烯基化合物： 其中 A 代表 X¹ 代表烷基、烷氧基、烷氧基烷基、芳氧基、环烷氧基、卤代烷氧基、烯氧基、芳氧基或卤素原子； X² 代表卤素原子； X³ 代表不超过 8 个碳原子的烷基、不超过 8 个碳原子的烷氧基或卤素原子； R¹ 代表具有氮原子的杂环；其中，当 n 或 m 分别为 2 或 3 时，每个 X¹ 或每个 X³ 相同或不同；当 n 或 m 分别为 2 或 3 时，每个 X² 相同或不同。
• TREAD RUBBER COMPOSITION AND PNEUMATIC TIRE
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP2857446A1

  公开（公告）日：2015-04-08

  Provided are a tread rubber composition that can achieve a balanced improvement in fuel economy, wet-grip performance, and abrasion resistance, and a pneumatic tire including the composition. The tread rubber composition includes: a rubber component; silica; and a silane-coupling agent containing a mercapto group, the rubber component including per 100% by mass thereof 5% by mass or more of a conjugated diene polymer (A), the polymer (A) including a monomer unit derived from a conjugated diene, a monomer unit derived from a compound of formula (1), and a monomer unit derived from a compound of formula (2), at least one end of the copolymer (A) being modified by the following compound (G) or an alkoxysilane compound, the composition including 5-150 parts by mass of the silica per 100 parts by mass of the rubber component, Compound (G): at least one compound selected from the group consisting of compounds containing an optionally-substituted amino group and a carbonyl group and compounds containing an optionally-substituted amino group and a thiocarbonyl group,         V1-S1     (1)         V2-A2     (2) wherein V1 and V2 each represent a hydrocarbyl group containing a polymerizable carbon-carbon double bond; S1 represents a substituted silyl group, and A2 represents a substituted amino group or a nitrogen-containing heterocyclic group.

  本文提供了一种可均衡改善燃油经济性、湿抓地性能和耐磨性的胎面橡胶组合物，以及一种包含该组合物的充气轮胎。胎面橡胶组合物包括橡胶成分；白炭黑和含有巯基的硅烷偶联剂，橡胶成分包括每 100% 质量中 5%（质量）或更多的共轭二烯聚合物 (A)，聚合物 (A) 包括衍生自共轭二烯的单体单元、衍生自式 (1) 化合物的单体单元和源自式（2）化合物的单体单元，共聚物（A）的至少一端由下列化合物（G）或烷氧基硅烷化合物改性，该组合物包括每 100 份（质量）橡胶成分中含 5-150 份（质量）二氧化硅的化合物（G）：至少一种选自以下组别的化合物：含有任选取代的氨基和羰基的化合物，以及含有任选取代的氨基和硫代羰基的化合物、 V1-S1 (1) V2-A2 (2) 其中 V1 和 V2 分别代表含有可聚合碳碳双键的烃基，S1 代表取代的硅烷基，A2 代表取代的氨基或含氮杂环基。