trans(?)-crotonoylamino-methacryloylamino-methane | 114426-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trans(?)-crotonoylamino-methacryloylamino-methane
• 英文别名: trans-crotonoylamino-methacryloylamino-methane；N-trans-Crotonoyl-N'-methacryloyl-methylendiamin；trans-Crotonoylamino-methacryloylamino-methan
• CAS: 114426-03-8
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: WBTHTASFKDMMEG-SNAWJCMRSA-N

物化性质

• 沸点：
  448.3±41.0 °C(predicted)
• 密度：
  1.026±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.33
• 重原子数：
  13.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  N-(羟甲基)-2-甲基-2-丙烯酰胺 、 1,2-二氯乙烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 trans(?)-crotonoylamino-methacryloylamino-methane
  参考文献：
  名称：

  RET proto-oncogene mutation in a mixed medullaryfollicular thyroid carcinoma

  摘要：

  A case of a patient with an uncommon thyroid carcinoma, showing histological and immunohistochemical features of both follicular and parafollicular cells is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as confirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma. (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343809