(benzotriazol-1-yl)diethoxymethane | 161806-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: (benzotriazol-1-yl)diethoxymethane
• 英文别名: (benzotriazol-1-yl)dietoxymethane；1-(Diethoxymethyl)benzotriazole
• CAS: 161806-75-3
• 化学式: C₁₁H₁₅N₃O₂
• 分子量: 221.259
• InChiKey: QZRZTWBDELGBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (benzotriazol-1-yl)diethoxymethane 在 对甲苯磺酸 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 1.5h， 生成 1-phenyl-1,3,3-triethoxypropane
  参考文献：
  名称：

  Lewis Acid-Catalyzed Additions of (Benzotriazol-1-yl)diethoxymethane to Enol Ethers and Enamides. New Syntheses of β-Alkoxyalkanal and β-Aminoalkanal Acetals

  摘要：

  Addition of (benzotriazol-1-yl)diethoxymethane 11 to various acyclic and cyclic enol ethers and enamides produces the corresponding adducts, which were reacted with either NaAlH4 or Grignard reagents to afford acyclic acetal-ethers (18a-f), cyclic alpha-(substituted)-beta-acetals (19a-c), amino-acetals (24a,b), and 1,3-amino-ethers (25), all known but previously difficult-to-access classes of compounds.

  DOI：

  10.1021/jo9612335
• 作为产物：
  描述：

  T406石油添加剂 、 原甲酸三乙酯 生成 (benzotriazol-1-yl)diethoxymethane
  参考文献：
  名称：

  Rutavichyus, A. I.; Iokubaitite, S. P., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 2371 - 2375

  摘要：

  DOI：

文献信息

• A New Method of Synthesis for Propargylic Amines and Ethers via Benzotriazole Derivatives Using Sodium Dialkynyldiethylaluminates
  作者：Jin Hee Ahn、Meyoung Ju Joung、Nung Min Yoon、Daniela C. Oniciu、Alan R. Katritzky

  DOI：10.1021/jo9814750

  日期：1999.1.1

  1-(alpha-Aminoalkyl)benzotriazoles react with sodium dialkynyldiethylaluminates to give propargylic amines in excellent yields, including unsubstituted N,N-dialkyl propargylamines, which are difficult to obtain from Lithium acetylide. The reaction of alpha-benzotriazolyl alkyl ethers and sodium dialkynyldiethylaluminate in the presence of zinc iodide also gives propargylic ethers in excellent yields. Unsubstituted propargyl ethers are prepared via the desilylation of trimethylsilylpropargyl ethers.
• Rutavichyus, A. I.; Iokubaitite, S. P., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 2371 - 2375
  作者：Rutavichyus, A. I.、Iokubaitite, S. P.

  DOI：——

  日期：——
• RUTAVICHYUS, A. J.;JOKUBAJTITE, S. P., ZH. ORGAN. XIMII, 1984, 20, N 12, 2604-2608
  作者：RUTAVICHYUS, A. J.、JOKUBAJTITE, S. P.

  DOI：——

  日期：——
• Lewis Acid-Catalyzed Additions of (Benzotriazol-1-yl)diethoxymethane to Enol Ethers and Enamides. New Syntheses of β-Alkoxyalkanal and β-Aminoalkanal Acetals
  作者：Alan R. Katritzky、Sergei A. Belyakov、Bogumila Rachwal、Jean-Luc Moutou

  DOI：10.1021/jo9612335

  日期：1997.2.1

  Addition of (benzotriazol-1-yl)diethoxymethane 11 to various acyclic and cyclic enol ethers and enamides produces the corresponding adducts, which were reacted with either NaAlH4 or Grignard reagents to afford acyclic acetal-ethers (18a-f), cyclic alpha-(substituted)-beta-acetals (19a-c), amino-acetals (24a,b), and 1,3-amino-ethers (25), all known but previously difficult-to-access classes of compounds.
• Katritzky, Alan R.; Ignatchenko, Alexey V.; Lang, Hengyuan, Heterocycles, 1995, vol. 41, # 1, p. 131 - 146
  作者：Katritzky, Alan R.、Ignatchenko, Alexey V.、Lang, Hengyuan

  DOI：——

  日期：——