2,2,5,5-tatramethyltetrahydrofuran | 102369-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2,2,5,5-tatramethyltetrahydrofuran
• 英文别名: 2,3,4,5-tetramethyl-tetrahydro-furan；2,3,4,5-Tetramethyl-tetrahydrofuran；2,3,4,5-Tetramethyltetrahydrofuran；2,3,4,5-tetramethyloxolane
• CAS: 102369-80-2
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: NCFAMFYCBVOFCN-UHFFFAOYSA-N

物化性质

• 沸点：
  136-137 °C
• 密度：
  0.8415 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2,5,5-tatramethyltetrahydrofuran 、 六羰基钨 、 水 在 C₆H₁₂ 作用下， 以 环己烷 为溶剂， 以0%的产率得到[W(CO)5(2,2,5,5-tetramethyltetrahydrofuran)]
  参考文献：
  名称：

  瞬态有机金属中配体取代的电子和立体效应：W（CO）5（环己烷）与（CH 3）n THF和（CH 3）n呋喃（n = 1，2）的反应

  摘要：

  时间分辨红外吸收光谱用于研究溶剂化的瞬态中间体W（CO）5（环己烷）与分子（L）2-甲基四氢呋喃（MeTHF），2,5-二甲基四氢呋喃（Me 2 THF），2的反应-甲基呋喃（MeFur）和2,5-二甲基呋喃（Me 2 Fur）。在所有四种情况下，在微秒至毫秒的时间尺度上观察到的唯一反应是环己烷分子的取代形成W（CO）5（L）。从反应速率常数的温度依赖性，在15-60℃的范围内测量的，我们确定下列激活参数：对于L = MeTHF中，Δ ħ ⧧ = 4.0±0.3千卡摩尔- 1，Δ小号⧧= -14.1±1.0 eu; 对于L =我2 THF，Δ ħ ⧧ = 4.3±0.3千卡摩尔- 1，Δ小号⧧ = -14.8±1.2 EU; 对于L = MeFur，Δ ħ ⧧ = 6.0±0.2千卡摩尔- 1，Δ小号⧧ = -10.2±1.2 EU; 和用于L =我2毛皮，Δ ħ ⧧ = 6.3±0.4千卡摩尔-

  DOI：

  10.1021/om000932b

文献信息

• GAMMA SECRETASE MODULATORS
  申请人：Huang Xianhai

  公开号：US20100137320A1

  公开（公告）日：2010-06-03

  This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).

  本发明提供了一种新型的化合物，它们是γ-分泌酶的调节剂。这些化合物的化学式如下：（见原文） 此外，本发明还揭示了调节γ-分泌酶活性的方法以及使用化合物（I）治疗阿尔茨海默病的方法。
• Activating organometallic composition for the (co) polymerization of alpha-olefins comprising fluorinated cyclopentadienyl compounds
  申请人：——

  公开号：US20040198934A1

  公开（公告）日：2004-10-07

  An organometallic composition which can be used as activating component in a metallocene catalyst for the (co)polymerization of &agr;-olefins, comprises: (A) a fluorinated di-unsaturated cyclic compound, having a relatively acid hydrogen atom, (B) an organometallic compound sufficiently basic to react with the acid hydrogen of the above compound (A), and (C) a polar aprotic organic compound, not containing metallic atoms, having a dielectric constant, in the pure state, equal to or greater than 2, and a weak coordinating capacity. Said composition allows a metallocene catalytic system of the ionic type to be obtained, with a high activity in the (co)polymerization of olefins and a reduced content of metallic residue in the polymeric product thus obtained.

  一种可以用作金属茂催化剂中活性组分的有机金属化合物，用于α-烯烃的(共)聚合反应，包括：(A)一种含有相对酸性氢原子的氟代二烯环化合物，(B)一种有机金属化合物，足够碱性以与上述化合物(A)的酸性氢原子反应，以及(C)一种极性非脂肪有机化合物，不含金属原子，在纯态下具有介电常数等于或大于2的弱配位能力。该组合物可以获得离子型金属茂催化系统，在α-烯烃的(共)聚合反应中具有高的活性，并且所得到的聚合物产品中含有较少的金属残留物。
• POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT
  申请人：Nagao Masato

  公开号：US20120088888A1

  公开（公告）日：2012-04-12

  To provide a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, a liquid crystal alignment film and a novel diamine which is useful as the starting material of these polymers. A polyimide precursor having polymerized units represented by the formula (1), and characterized by satisfying any one of the following (i) to (iii): (i) the structure of X, Y or each of them in formula (1) has a group represented by the following formula (2); (ii) R 2 , R 3 or each of them in formula (1) is a group represented by the following formula (2); (iii) the structure of X, Y or each of them in formula (1) has a group represented by the following formula (2), and R 2 , R 3 or each of them is a group represented by following formula (2):

  提供一种新型聚酰亚胺前体或聚酰亚胺，可提供具有低体积电阻率的液晶取向膜，包含这些聚合物的液晶取向剂，液晶取向膜和一种新型二胺，作为这些聚合物的起始材料。聚酰亚胺前体具有由式（1）表示的聚合单元，其特征在于满足以下任一条件（i）至（iii）中的任一条件：（i）式（1）中的X、Y或它们中的每一个具有以下式（2）表示的基团的结构；（ii）式（1）中的R2、R3或它们中的每一个是以下式（2）表示的基团；（iii）式（1）中的X、Y或它们中的每一个具有以下式（2）表示的基团的结构，而R2、R3或它们中的每一个是以下式（2）表示的基团。
• LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20160244673A1

  公开（公告）日：2016-08-25

  To provide a liquid crystal aligning agent to obtain a liquid crystal alignment film which is excellent in the adhesion to a sealing agent and in the liquid crystal alignment property. A liquid crystal aligning agent containing at least one polymer selected from the group consisting of a polyimide precursor having structural units represented by the formula (1) and structural units represented by the formula (3) and an imidized polymer of the polyimide precursor: wherein X 1 and X 4 are a tetravalent organic group, Y 1 is a bivalent organic group having a thermally-leaving group, Y 2 is a bivalent organic group, R 1 and R 2 are a hydrogen atom or a C 1-5 alkyl group, and Z 1 and Z 2 are a hydrogen atom, or a C 1-10 alkyl group, C 2-10 alkenyl group or C 2-10 alkynyl group which may have a substituent.

  提供一种液晶定向剂，以获得具有优异密封剂附着性和液晶定向性的液晶定向膜。所述液晶定向剂包含至少一种聚合物，所述聚合物从以下组中选择：具有由公式（1）和公式（3）表示的结构单元的聚酰亚胺前体和聚酰亚胺前体的缩酐聚合物：其中X1和X4是四价有机基团，Y1是具有热离基的双价有机基团，Y2是双价有机基团，R1和R2是氢原子或C1-5烷基基团，Z1和Z2是氢原子或C1-10烷基基团、C2-10烯基基团或C2-10炔基基团，可以具有取代基。
• LIQUID CRYSTAL ALIGNING AGENT CONTAINING POLYIMIDE PRECURSOR HAVING THERMALLY-LEAVING GROUP AND/OR POLYIMIDE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20160264867A1

  公开（公告）日：2016-09-15

  To provide a liquid crystal aligning agent to obtain a liquid crystal alignment film which is excellent in the adhesion to a sealing agent and a substrate of a liquid crystal display device, and of which a decomposed product formed after irradiation with ultraviolet rays will easily be removed. A liquid crystal aligning agent containing at least one polymer selected from the group consisting of a polyimide precursor having a bond represented by the following formula (1) in its main chain and an imidized polymer of the polyimide precursor: wherein each of R 1 , R 2 , R 3 and R 4 which are independent of one another, is a hydrogen atom or a C 1-20 monovalent hydrocarbon group which may have a substituent, and D is a protecting group to be replaced with a hydrogen atom by heat.

  提供一种液晶定向剂，以获得在液晶显示器的密封剂和基板上具有优异附着性的液晶定向膜，并且在紫外线照射后形成的分解产物易于去除。该液晶定向剂包含至少一种聚合物，所述聚合物从以下群组中选择：具有其主链中表示如下式（1）的键的聚酰亚胺前体和聚酰亚胺前体的缩合聚合物：其中，R1、R2、R3和R4各自独立地是氢原子或C1-20个单价烃基，可以具有取代基，D是保护基，可通过热被氢原子取代。