(S)-2-butyl-3-phenyl-prop-1-en-3-ol | 1221690-44-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-2-butyl-3-phenyl-prop-1-en-3-ol
• CAS: 1221690-44-3
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: WLHQPYDCNSJFTJ-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.47
• 重原子数：
  14.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  在 disodium hydrogenphosphate 、 sodium-mercury amalgam (5%) 作用下， 以 甲醇 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  远程诱导芳基格氏试剂立体选择性1,2-加成至β-亚磺酰基烯酮

  摘要：

  旋光性叔烯丙基醇是有机合成中重要且通常具有挑战性的目标。在这项工作中，我们使用β-亚磺酰基部分作为远程手性助剂，以实现芳基格氏试剂与烯酮的不对称1,2-加成反应，从而形成多种光学活性的叔烯丙基醇。代表性醇产物的绝对构型通过X射线晶体学测定。

  DOI：

  10.1016/j.tetlet.2013.12.108

文献信息

• Dramatic Improvement in Catalyst Loadings and Molar Ratios of Coupling Partners for Ni/Cr-Mediated Coupling Reactions: Heterobimetallic Catalysts
  作者：Xiang Liu、James A. Henderson、Takeo Sasaki、Yoshito Kishi

  DOI：10.1021/ja9079308

  日期：2009.11.25

  Two new ligands 1a,b are reported. Upon treatment with 1 equiv of NiCl2 center dot(MeOCH2)(2), 1a,b give the corresponding Ni complexes. X-ray analysis of 1a-NiCl2 established that the NiCl2 is selectively coordinated to the phenanthroline nitrogens. Ni/Cr heterobimetallic catalysts 1a,b center dot CrCl2/NiCl2, prepared from 1a,b center dot NiCl2, have been shown to behave exceptionally well in catalytic asymmetric Ni/Cr-mediated couplings, with highlights including the following: (1) 1-2 mol % catalyst is sufficient to complete the coupling; (2) only negligible amounts of the dimers, byproducts formed through the alkenyl Ni species, are observed; (3) the coupling goes to completion even with a 1:1 molar ratio of the coupling partners; and (4) the asymmetric induction is practically identical with that obtained from the coupling with the Cr catalysts prepared from (S)-sulfonamides 2a,b. The scope of the new Ni/Cr heterobimetallic catalysts was briefly studied using four additional aldehydes. The applicability of the new catalysts to polyfunctional substrates was demonstrated by two C-C bond formations chosen from the hatichondrin/E7389 synthesis as examples.