(S)-3-isobutyl-2-methylisothiazolidine 1,1-dioxide | 1613639-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (S)-3-isobutyl-2-methylisothiazolidine 1,1-dioxide
• 英文别名: (3S)-2-methyl-3-(2-methylpropyl)-1,2-thiazolidine 1,1-dioxide
• CAS: 1613639-86-3
• 化学式: C₈H₁₇NO₂S
• 分子量: 191.294
• InChiKey: CXEYESSQQDGJGW-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘苯 、 (S)-3-isobutyl-2-methylisothiazolidine 1,1-dioxide 在 2,2,6,6-tetramethylpiperidylzinc chloride lithium chloride 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以50%的产率得到
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Sultams with Aryl and Heteroaryl Iodides

  摘要：

  Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.

  DOI：

  10.1021/ol501389k
• 作为产物：
  描述：

  L-亮氨醇 在 正丁基锂 、 三乙胺 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 18.0h， 生成 (S)-3-isobutyl-2-methylisothiazolidine 1,1-dioxide
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Sultams with Aryl and Heteroaryl Iodides

  摘要：

  Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.

  DOI：

  10.1021/ol501389k

文献信息

• Palladium-Catalyzed α-Arylation of Sultams with Aryl and Heteroaryl Iodides
  作者：Olivier René、Benjamin P. Fauber、Sushant Malhotra、Herbert Yajima

  DOI：10.1021/ol501389k

  日期：2014.7.3

  Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.