2-氟丙-2-烯-1-胺 | 5675-32-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 2-氟丙-2-烯-1-胺
• 英文名称: 2-fluoroprop-2-en-1-amine
• 英文别名: 2-fluoroallylamine；3-Amino-2-fluoropropene；3-Amino-2-fluoro-1-propene
• CAS: 5675-32-1
• 化学式: C₃H₆FN
• mdl: MFCD19206387
• 分子量: 75.0857
• InChiKey: LMPNVBOFEQPGQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氟丙-2-烯-1-胺 生成 2,2,2-trifluoro-N-(2-fluoroallyl)acetamide
  参考文献：
  名称：

  INHIBITORS OF VAP-1

  摘要：

  Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

  公开号：

  US20230295140A1
• 作为产物：
  描述：

  2-(2-fluoroallyl)isoindoline-1,3-dione 在 一水合肼 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以68%的产率得到2-氟丙-2-烯-1-胺
  参考文献：
  名称：

  Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions

  摘要：

  多种取代的N-Boc保护的4-(烯丙胺甲基)-2(5H)-呋喃酮的分子内[2+2]光环加成反应，产生具有三个空间上定义的位置供进一步功能化的高刚性产物（53-75%）。

  DOI：

  10.1039/c3cc40757h

文献信息

• Photochemical Reactions of Prop-2-enyl and Prop-2-ynyl Substituted 4-Aminomethyl- and 4-Oxymethyl-2(5H)-furanones
  作者：Thorsten Bach、Diego A. Fort、Thomas J. Woltering、André M. Alker

  DOI：10.3987/com-13-s(s)67

  日期：——

  Compounds with a heterocyclic 9-oxatricyclo[5.3.0.0(1,5)]decan-8-one skeleton were synthesized by intramolecular [2+2] photocycloaddition reactions of the title compounds (lambda = 254 nm, Et2O or MeCN as the solvent). Starting from various substituted 4-(prop-2-enylaminomethyl)-2(5H)-furanones, products 5, 9, 18, 21, 23, 24 were obtained, which bear a nitrogen atom in position 3 of this skeleton within a pyrrolidine ring. The Boc or Cbz groups represent suitable nitrogen protecting groups, which were compatible with the irradiation conditions and which can be easily cleaved. In an analogous fashion an oxygen (product 22) and carbon substituent (product 25) could be implemented at position 3 of the product if the starting material was appropriately chosen. The prop-2-ynyl substituted substrates did not produce a [2+2] photocycloaddition product but rather underwent a cyclization to spiro products 11 and 13.
• An Intramolecular [2 + 2] Photocycloaddition Approach to Conformationally Restricted Bis-Pyrrolidines
  作者：Diego A. Fort、Thomas J. Woltering、André M. Alker、Thorsten Bach

  DOI：10.1021/jo501302f

  日期：2014.8.1

  With N-Boc-protected 4-(allylaminomethyl)-2-(5H)furanones as starting materials, a photochemical approach is presented to give 3,9-diazatricyclo[5.3.0.0(1,5)]decanes as conformationally restricted bis-pyrrolidines. The products are orthogonally protected at the two nitrogen atoms and exhibit, depending on the substitution pattern at positions C5, C6, and C7, latent C-2 symmetry. When the furanones had a phenyl group at the 3-position (X-3), alternative photochemical pathways were observed.
• Chlorination of 2-fluoropropene. 3-Chloro-2-fluoropropene and some of its derivatives
  作者：Leonard Oro Moore、Joseph P. Henry、Jared W. Clark

  DOI：10.1021/jo00837a009

  日期：1970.12