4-氯-2-甲基苯硼酸 | 209919-30-2

• 物质功能分类: 化学试剂 - 有机试剂 - 硼酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氯-2-甲基苯硼酸
• 中文别名: 4-氯邻甲基苯硼酸；4-氯-2-甲基苯基硼酸；2-甲基-4-氯苯硼酸
• 英文名称: 4-chloro-2-methylphenylboronic acid
• 英文别名: 2-methyl-4-chlorophenylboronic acid；(4-chloro-2-methylphenyl)boronic acid
• CAS: 209919-30-2
• 化学式: C₇H₈BClO₂
• 分子量: 170.403
• InChiKey: SRXXSLUUAWHGBZ-UHFFFAOYSA-N

物化性质

• 熔点：
  193-195°C
• 沸点：
  314.9±52.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)
• 溶解度：
  溶于甲醇
• 稳定性/保质期：
  避氧化物

计算性质

• 辛醇/水分配系数(LogP)：
  0.33
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S26,S36,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

4-Chloro-2-methylphenylboronic Acid (contains varying Revision number: 6
amounts of Anhydride)
SAFETY DATA SHEET

---

Section 1. IDENTIFICATION
Product name: 4-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)

Revision number: 6

---

Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Warning
Signal word
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
4-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Components:
Percent: ....
209919-30-2
CAS Number:
Synonyms: 4-Chloro-2-methylbenzeneboronic Acid (contains varying amounts of Anhydride) , 4-
Chloro-o-tolylboronic Acid (contains varying amounts of Anhydride)
Chemical Formula: C7H8BClO2
varying amounts of Anhydride)

---

Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
varying amounts of Anhydride)

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Form: Crystal- Powder
Colour: White - Very pale yellow
Odour: No data available
pH: No data available
Melting point/freezing point:195°C
Boiling point/range: No data available
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
[Water] No data available
[Other solvents]
Soluble: Methanol

---

Section 10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Boron oxides , Hydrogen chloride
products:

---

Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

---

Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
No data available
Log Pow:
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

---

Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
varying amounts of Anhydride)

---

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

---

Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-氯-2-甲基苯硼酸 在 dipotassium peroxodisulfate 、 四丁基溴化铵 、 iron(II) chloride 作用下， 以 水 、 乙腈 为溶剂， 生成 4-氯-2-醛基苯硼酸
  参考文献：
  名称：

  [EN] FLOW REACTION PROCESS FOR MANUFACTURE OF BORON-CONTAINING AGROCHEMICALS
  [FR] PROCÉDÉ DE RÉACTION D'ÉCOULEMENT POUR LA FABRICATION DE PRODUITS AGROCHIMIQUES CONTENANT DU BORE

  摘要：

  本发明涉及制备苯并硼酸酯的方法。苯并硼酸酯化合物已经显示出作为抗真菌病原体的抗菌剂的潜力。该发明还涉及无环烷氧基硼酸酯作为中间体的组合物，以及将中间体与有机镁、镁或有机锂试剂混合形成所需的苯并硼酸酯的连续流程。

  公开号：

  WO2021021932A1
• 作为产物：
  描述：

  2-溴-5-氯甲苯 在 正丁基锂 、 硼酸三异丙酯 、 盐酸 作用下， 以 四氢呋喃 、 正己烷 、 水 为溶剂， 反应 2.0h， 以81%的产率得到4-氯-2-甲基苯硼酸
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC BONE DISEASES CONTAINING ALPHA-ARYLMETHOXYACRYLATE DERIVATIVES
  [FR] COMPOSITION PHARMACEUTIQUE DESTINEE A PREVENIR ET A TRAITER DES MALADIES OSSEUSES METABOLIQUES, CONTENANT DES DERIVES D'ALPHA-ARYLMETHOXYACRYLATE

  摘要：

  本发明涉及使用特定的α-芳基甲氧基丙烯酸酯衍生物，或其药理学上可接受的盐或溶剂，用于预防和治疗代谢性骨疾病。

  公开号：

  WO2005123054A1

文献信息

• Synthesis of <i>ortho</i>-Phenolic Sulfilimines via an Intermolecular Sulfur Atom Transfer Cascade Reaction
  作者：Feng Xiong、Yingying Zuo、Yinan Song、Linxing Zhang、Xinhao Zhang、Shaojian Xu、Yan Ren

  DOI：10.1021/acs.orglett.0c01032

  日期：2020.5.15

  To expand the toolbox for the synthesis of ortho-phenolic sulfilimines, sigmatropic rearrangements were introduced to the field of sulfilimine chemistry. Herein we report a N-H sulfenylation/[2,3]-sigmatropic rearrangement cascade reaction. This mild reaction enables commercially available thiols to serve as the sulfenylation reagent and generates water as the sole byproduct. Moreover, the reaction

  为了扩展用于合成邻苯酚亚硫亚胺的工具箱，将σ重排引入亚硫亚胺化学领域。在这里，我们报告一个NH亚磺酰化/ [2,3] -sigmatropic重排级联反应。这种温和的反应使可商购的硫醇充当亚磺酰化试剂，并产生水作为唯一的副产物。此外，该反应具有广泛的底物范围，并且可以以克规模进行，具有优异的反应效率。
• C(acyl)–C(sp²) and C(sp²)–C(sp²) Suzuki–Miyaura cross-coupling reactions using nitrile-functionalized NHC palladium complexes
  作者：Sinem Çakır、Serdar Batıkan Kavukcu、Hande Karabıyık、Senthil Rethinam、Hayati Türkmen

  DOI：10.1039/d1ra07231e

  日期：——

  N-heterocyclic carbene (NHC) palladium complexes has been successful for the modulation of C–C coupling reactions. For this purpose, a series of azolium salts (1a–f) including benzothiazolium, benzimidazolium, and imidazolium, bearing a CN-substituted benzyl moiety, and their (NHC)2PdBr2 (2a–c) and PEPPSI-type palladium (3b–f) complexes have been systematically prepared to catalyse acylative Suzuki–Miyaura

  N-杂环卡宾（NHC）钯配合物的应用已成功用于调节C-C偶联反应。为此，包括苯并噻唑鎓、苯并咪唑鎓和咪唑鎓在内的一系列唑鎓盐 ( 1a-f )，带有 CN 取代的苄基部分，以及它们的 (NHC) 2 PdBr 2 ( 2a-c ) 和 PEPPSI 型钯 ( 3b -F) 已系统地制备了配合物以催化酰氯与芳基硼酸的酰化 Suzuki-Miyaura 偶联反应，在碳酸钾作为碱存在下形成二苯甲酮衍生物，并催化溴苯与芳基硼酸的传统 Suzuki-Miyaura 偶联反应形成联芳基。所有合成的化合物均通过傅里叶变换红外 (FTIR) 和1 H 和13 C NMR 光谱进行了充分表征。3c、3e和3f单晶的X射线衍射研究证明正方形平面几何。进行了扫描电子显微镜 (SEM)、能量色散 X 射线光谱 (EDS)、金属映射分析和热重分析 (TGA)，以进一步了解 Suzuki-Miyaura 交叉偶联反应的机制。机理研究表明，CN
• Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
  申请人：Akerman Michelle

  公开号：US20060004012A1

  公开（公告）日：2006-01-05

  The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L 1 -P-L 2 -M-X-L 3 -A wherein the definitions of the variables Q, L 1 , P, L 2 , M, X, L 3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

  本发明提供了一种有用的化合物，例如，用于调节受试者体内胰岛素水平的化合物，其具有以下一般公式 Q-L1-P-L2-M-X-L3-A 其中变量Q、L1、P、L2、M、X、L3和A的定义在此处提供。本发明还提供了用于这些化合物的组合物和方法，例如，用于治疗2型糖尿病。
• PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160089364A1

  公开（公告）日：2016-03-31

  The invention relates to a pharmaceutical composition for non-hormonal, on-demand contraception and to processes for preparing this pharmaceutical composition. The latter comprises 2H-indazole as novel EP2 receptor antagonists in combination with COX inhibitors. The invention furthermore provides a method for non-hormonal female-controlled on-demand contraception where a pharmaceutical composition comprising EP2 receptor antagonists in combination with COX inhibitors is taken on demand prior to expected sexual intercourse.

  这项发明涉及一种用于非激素、按需避孕的药物组合物，以及制备该药物组合物的方法。后者包括2H-吲哚唑作为新型EP2受体拮抗剂，与COX抑制剂结合使用。该发明还提供了一种非激素女性控制的按需避孕方法，其中在预期性交前按需服用含有EP2受体拮抗剂与COX抑制剂的药物组合物。
• The Discovery of a Palladium(II)-Initiated Borono-Catellani Reaction
  作者：Shuqing Chen、Ze-Shui Liu、Tao Yang、Yu Hua、Zhiyu Zhou、Hong-Gang Cheng、Qianghui Zhou

  DOI：10.1002/anie.201803865

  日期：2018.6.11

  Reported is a novel palladium(II)‐initiated Catellani‐type reaction that utilizes widely accessible aryl boronic acids as the substrates instead of aryl halides, thereby greatly expanding the existing scope of this powerful transformation. This borono‐Catellani reaction was promoted by cooperative catalysis between Pd(OAc)2 and the inexpensive 5‐norbornene‐2‐carbonitrile. Practicality is the striking

  据报道，是一种新颖的钯（II）引发的卡塞拉尼型反应，该反应利用可广泛使用的芳基硼酸而不是卤代芳基作为底物，从而大大扩展了这种有力转化的现有范围。Pd（OAc）2之间的协同催化促进了这种硼诺-卡泰拉尼反应以及价格低廉的5-降冰片烯2-腈。实用性是该反应的显着特征：它在环境温度下对空气开放，不需要膦配体。这种温和，化学选择性和可扩展的方案与各种现成的官能化芳基硼酸和溴化物以及终止烯烃（50例，收率39–97％）兼容。此外，还证实了卡诺拉尼和经典卡特兰尼反应之间的正交反应性。预期这项工作将为开发新颖的卡泰拉尼型反应开辟新途径。