N,N'-dimethyl-N,N'-bis[[2-[(R)-methylsulfinyl]phenyl]methyl]ethane-1,2-diamine | 1246366-77-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-dimethyl-N,N'-bis[[2-[(R)-methylsulfinyl]phenyl]methyl]ethane-1,2-diamine
• CAS: 1246366-77-7
• 化学式: C₂₀H₂₈N₂O₂S₂
• 分子量: 392.587
• InChiKey: CDFVLFZLGGGIQQ-CLJLJLNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (R,R)-(+)-N1,N2-bis-(2-(methylsulfinyl)benzyl)ethane-1,2-diamine 在 溶剂黄146 、 sodium cyanoborohydride 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以90%的产率得到N,N'-dimethyl-N,N'-bis[[2-[(R)-methylsulfinyl]phenyl]methyl]ethane-1,2-diamine
  参考文献：
  名称：

  New chiral imino- and amino-sulfoxides as activators of allyl trichlorosilane in the asymmetric allylation of aldehydes

  摘要：

  Chiral 2-methylsulfinyl benzaldehyde proved to be a valuable starting material for a convenient approach towards a variety of imino- and amino-sulfoxides. The catalytic properties of these new ligands, as potential activators of allyl trichlorosilane, have been exploited in new catalytic procedures for the synthesis of enantioenriched homoallylic alcohols. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.015
• 作为试剂：
  描述：

  苯丙醛 、 丙烯基三氯硅烷 在 N,N'-dimethyl-N,N'-bis[[2-[(R)-methylsulfinyl]phenyl]methyl]ethane-1,2-diamine 、 四丁基溴化铵 、 N,N-二异丙基乙胺 、 水 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 生成 (S)-1-phenyl-5-hexen-3-ol 、 (R)-1-phenyl-hex-5-en-3-ol
  参考文献：
  名称：

  New chiral imino- and amino-sulfoxides as activators of allyl trichlorosilane in the asymmetric allylation of aldehydes

  摘要：

  Chiral 2-methylsulfinyl benzaldehyde proved to be a valuable starting material for a convenient approach towards a variety of imino- and amino-sulfoxides. The catalytic properties of these new ligands, as potential activators of allyl trichlorosilane, have been exploited in new catalytic procedures for the synthesis of enantioenriched homoallylic alcohols. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.015

文献信息

• New chiral imino- and amino-sulfoxides as activators of allyl trichlorosilane in the asymmetric allylation of aldehydes
  作者：Vincenzo De Sio、Maria Rosaria Acocella、Rosaria Villano、Arrigo Scettri

  DOI：10.1016/j.tetasy.2010.04.015

  日期：2010.6

  Chiral 2-methylsulfinyl benzaldehyde proved to be a valuable starting material for a convenient approach towards a variety of imino- and amino-sulfoxides. The catalytic properties of these new ligands, as potential activators of allyl trichlorosilane, have been exploited in new catalytic procedures for the synthesis of enantioenriched homoallylic alcohols. (C) 2010 Elsevier Ltd. All rights reserved.