ethyl 2-methylene-6-phenylhexanoate | 78573-20-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-methylene-6-phenylhexanoate
• 英文别名: 6-phenyl-2-methylenehexanoic acid ethyl ester；Ethyl 2-methylidene-6-phenylhexanoate
• CAS: 78573-20-3
• 化学式: C₁₅H₂₀O₂
• 分子量: 232.323
• InChiKey: GRFGNTHEYGVJEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl 2-methylene-6-phenylhexanoate 在 六甲基二硅氮烷 、 silver(l) oxide 作用下， 以 氯仿 为溶剂， 反应 4.5h， 生成 Ethyl 2-[[1-adamantyloxy-[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-6-phenylhexanoate
  参考文献：
  名称：

  Phosphinic Pseudo-Tripeptides as Potent Inhibitors of Matrix Metalloproteinases:  A Structure−Activity Study

  摘要：

  Several phosphinic pseudo-tripeptides of general formula R-Xaa Psi (PO2-CH2)Xaa'-Yaa'-NH2 were synthesized and evaluated for their in vitro activities to inhibit stromelysin-3, gelatinases A and B, membrane type-1 matrix metalloproteinase, collagenases 1 and 2, and matrilysin. With the exception of collagenase-1 and matrilysin, phosphinic pseudo-tripeptides behave as highly potent inhibitors of matrix metalloproteinases, provided they contain in P-1' position an unusual long aryl-alkyl substituent. Study of structure-activity relationships regarding the influence of the R and Xaa' substituents in this series may contribute to the design of inhibitors able to block only a few members of the matrix metalloproteinase family.

  DOI：

  10.1021/jm9900164
• 作为产物：
  描述：

  聚合甲醛 、 4-phenylbutylmalonic acid monoethyl ester 在 哌啶 、 吡啶 作用下， 反应 4.0h， 以78%的产率得到ethyl 2-methylene-6-phenylhexanoate
  参考文献：
  名称：

  苯基烷基环氧乙烷羧酸衍生物的合成及其降血糖活性。

  摘要：

  已经合成了一系列新的2-（苯基烷基）环氧乙烷-2-羧酸，并研究了其对血糖浓度的影响。大多数化合物在禁食大鼠中表现出显着的降血糖活性。结构活性研究表明，苯环上的取代基（如Cl或CF3）和三至五个碳原子的链长是最有效的物质。在这些化合物中，2- [5-（4-氯苯基）戊基]环氧乙烷-2-羧酸乙酯（36）表现出最有利的活性。

  DOI：

  10.1021/jm00344a003

文献信息

• Structure based optimization of chromen-based TNF-α converting enzyme (TACE) inhibitors on S1′ pocket and their quantitative structure–activity relationship (QSAR) study
  作者：Jee Sun Yang、Kwangwoo Chun、Jung Eun Park、Misun Cho、Jeongjea Seo、Doona Song、Hongchul Yoon、Chun-Ho Park、Bo-Young Joe、Jong-Hee Choi、Myung-Hwa Kim、Gyoonhee Han

  DOI：10.1016/j.bmc.2010.10.006

  日期：2010.12

  structure–activity relationship (QSAR) study using genetic function approximation technique (GFA) and docking study were performed to confirm the series of coumarin core TACE inhibitors. QSAR model have been evaluated internally and externally using test set prediction. Through docking study of each molecule, it is validated that the electrostatic descriptors from the QSAR equation could explain the importance

  根据对接研究，设计了一系列基于香豆素的TACE抑制剂以结合在TACE酶的S1'口袋中。合成了十二个类似物，大多数化合物具有体外TACE酶抑制作用以及细胞TNF-α抑制作用。其中15μl通过以30mg / kg的剂量口服有效抑制血清TNF-α的产生。化合物15l在角叉菜胶模型中也显示出42％的良好口服生物利用度，并有效抑制爪水肿。使用遗传功能近似技术（GFA）进行了定量构效关系（QSAR）研究和对接研究，以确认一系列香豆素核心TACE抑制剂。QSAR模型已使用测试集预测在内部和外部进行了评估。通过对每个分子的对接研究，证实了QSAR方程中的静电描述符可以很好地解释S1'口袋和TACE抑制活性的重要性。
• Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives
  作者：Klaus Eistetter、Horst P. O. Wolf

  DOI：10.1021/jm00344a003

  日期：1982.2

  A series of new 2-(phenylalkyl)oxirane-2-carboxylic acids has been synthesized and studied for its effects on the concentration of blood glucose. Most of the compounds exhibit remarkable blood glucose lowering activities in fasted rats. Structure-activity studies reveal that substituents like Cl or CF3 on the phenyl ring and a chain length of three to five carbon atoms lead to the most effective substances

  已经合成了一系列新的2-（苯基烷基）环氧乙烷-2-羧酸，并研究了其对血糖浓度的影响。大多数化合物在禁食大鼠中表现出显着的降血糖活性。结构活性研究表明，苯环上的取代基（如Cl或CF3）和三至五个碳原子的链长是最有效的物质。在这些化合物中，2- [5-（4-氯苯基）戊基]环氧乙烷-2-羧酸乙酯（36）表现出最有利的活性。
• Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals
  作者：Jia-Bin Han、Ao Guo、Xiang-Ying Tang

  DOI：10.1002/chem.201806138

  日期：2019.2.26

  challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic

  从容易获得的醇衍生物开发了具有挑战性的烷氧基自由基脱氧剂，可在温和的反应条件下轻松合成具有良好官能团耐受性的官能化烯烃。由于烷氧基自由基很容易发生β片段分解或夺氢现象，因此这种使烷氧基自由基脱氧的新策略非常有价值。此外，机理研究表明，电子中性膦可作为脱氧剂。
• Substituted oxiranecarboxylic acids, their use and medicaments
  申请人：BYK Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung

  公开号：US04324796A1

  公开（公告）日：1982-04-13

  Substituted oxiranecarboxylic acids of the formula ##STR1## wherein R.sup.1 denotes a hydrogen atom (--H), a halogen atom, a hydroxyl roup, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R.sup.2 has one of the meanings of R.sup.1, R.sup.3 denotes a hydrogen atom (--H) or a lower alkyl group and n denotes an integer from 1 to 5, and the salts of the acids are new compounds. They display a hypoglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds and of the intermediate products required for their preparation are described.

  公式为 ##STR1## 的替代环氧丙酸，其中R.sup.1表示氢原子（-H），卤素原子，羟基，低碳基，低烷氧基或三氟甲基基团，R.sup.2具有R.sup.1的意义之一，R.sup.3表示氢原子（-H）或低碳基，n表示1到5的整数，酸的盐是新化合物。它们在温血动物中显示出降糖作用。描述了制备新化合物和制备所需的中间产物的过程。
• EISTETTER, K.;WOLF, H. P. O., J. MED. CHEM., 1982, 25, N 2, 109-113
  作者：EISTETTER, K.、WOLF, H. P. O.

  DOI：——

  日期：——