4H-Benzothiazin-1,3 | 254-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4H-Benzothiazin-1,3
• 英文别名: 4H-benzo[e][1,3]thiazine；4H-1,3-Benzothiazine
• CAS: 254-44-4
• 化学式: C₈H₇NS
• 分子量: 149.216
• InChiKey: OZKJZYPVNPFPSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4H-Benzothiazin-1,3 、 苯甲酰氯 生成 2-Benzoyl-4H-1,3-benzothiazine
  参考文献：
  名称：

  Bourgoin-Legay,D.; Boudet,R., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971, vol. 273, p. 372 - 374

  摘要：

  DOI：
• 作为产物：
  描述：

  三溴甲烷 、 2-aminomethyl-benzenethiol 生成 4H-Benzothiazin-1,3
  参考文献：
  名称：

  Bourgoin-Legay,D.; Boudet,R., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971, vol. 273, p. 372 - 374

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20170158680A1

  公开（公告）日：2017-06-08

  The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

  本发明提供了一种由公式（I）表示的杂环化合物，其立体异构体，或其药用可接受的盐，其药物组合物，以及它们用于制备预防或治疗中枢神经系统疾病的药物。
• Inhibitors of the Human Aldosterone Sythase CYP11B2
  申请人：Hartmann Rolf W.

  公开号：US20110112067A1

  公开（公告）日：2011-05-12

  The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.

  该发明提供了一般式(I)的化合物，这些化合物是人类醛固酮合成酶的抑制剂，还包括含有这些化合物的药物组合物，以及使用这些化合物治疗高醛固酮症和/或由11β-羟化酶（CYP11B1）介导的疾病或疾病的方法。
• [EN] PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS<br/>[FR] DÉRIVÉS DE PIPÉRIDIN-1-YL-N-PYRYDINE-3-YL-2-OXO-ACÉTAMIDE UTILES POUR LE TRAITEMENT DE CANCERS DÉFICIENTS EN MTAP ET/OU ACCUMULANT MTA
  申请人：TANGO THERAPEUTICS INC

  公开号：WO2022026892A1

  公开（公告）日：2022-02-03

  Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

  根据公式（I）提供化合物及其药用盐，以及药物组合物；其中R1、R2、R3、R4、R6、R7、R8和n的定义如本文所述。本发明的化合物被认为对预防和治疗各种疾病条件有用。
• 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2
  申请人：Hartmann Rolf W.

  公开号：US20110118241A1

  公开（公告）日：2011-05-19

  The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).

  本发明提供了一般式(I)的化合物，它们是人类醛固酮合成酶的抑制剂，还提供了含有这些化合物的制药组合物以及使用这些化合物和其他杂环取代喹啉酮衍生物治疗高醛固酮症和/或11β-羟化酶(CYP11B1)介导的疾病或疾病的方法。
• Oxidative hair dyeing method, composition and kit utilizing hydroxyl substituted benzothiazines
  申请人：Bristol-Myers Squibb Company

  公开号：EP0661039A1

  公开（公告）日：1995-07-05

  A process of dyeing hair by preparing and applying to the hair an aqueous reaction medium comprising dihydroxybenzothiazine and a periodsate, iodate, ferricyanide or persulfate oxidizing agent, the composition optionally containing a color modifier selected from the group consisting of direct dyes, primary intermediates, couplers, cysteine, dopa species and mixtures thereof, additionally containing a buffer to maintain the pH in the range from 2 to 11 during the oxidation reaction; and removing the aqueous reaction medium from the hair after the desired color is attained and compositions and kits for practicing such processes. The reaction medium may be formed by simultaneous addition of the benzothiazine and the oxidant to the hair or by addition of the benzothiazine followed addition of the oxidant.

  一种染发工艺，通过制备并在头发上涂抹由二羟基苯并噻嗪和过硫酸盐、碘酸盐、铁氰化物或过硫酸盐氧化剂组成的水性反应介质，该组合物可选择性地含有选自直接染料、初级中间体、偶联剂、半胱氨酸、多巴物及其混合物组成的组的颜色调节剂，此外还含有缓冲剂，以在氧化反应期间将pH值保持在2至11的范围内；在达到所需的颜色后，从头发上去除水性反应介质，以及用于实施此类工艺的组合物和试剂盒。反应介质可通过向头发同时添加苯并噻嗪和氧化剂形成，或通过添加苯并噻嗪后再添加氧化剂形成。