1,4-bis(2-iodoethoxy)benzene | 888721-91-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,4-bis(2-iodoethoxy)benzene
• CAS: 888721-91-3
• 化学式: C₁₀H₁₂I₂O₂
• 分子量: 418.013
• InChiKey: HBSAQRLLZMOOIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-bis(2-iodoethoxy)benzene 在 聚合甲醛 、 三氟化硼乙醚 作用下， 以31%的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units

  摘要：

  In this study, pillar[5]arene containing ten terminal alkynyl-functional group was prepared and carried out an optimization procedure for target molecule with using 5-hydroxyquinoline molecule known with biological activity. The novel molecule was named as iso-QP[5] and characterized by FT-IR, melting point, NMR, elemental analysis, and mass spectroscopy. The aim was to evaluate the anticancer effects of iso-QP[5] on MCF7 human breast cancer cells. The IC50 dose of iso-QP[5] in MCF7 cells was found to be 25 mu M for 24 h using XTT assay. Expressions of eight genes for apoptosis were determined by qPCR. The results showed a significant increase in the expression of BAX, CASP3, CASP9, CYCS, and P53 genes after treatment with iso-QP[5] in MCF7 cells. However, iso-QP[5] treatment significantly decreased expression of BCL2 and CASP8 genes. It is concluded that novel molecule iso-QP[5] caused apoptosis by regulating genes that are important in apoptosis in human breast cancer cells.

  DOI：

  10.1007/s00044-020-02547-y
• 作为产物：
  描述：

  1,4-bis(2-(methylsulfonyloxy)ethoxy)benzene 在 sodium iodide 作用下， 以 丙酮 为溶剂， 以93%的产率得到1,4-bis(2-iodoethoxy)benzene
  参考文献：
  名称：

  Regio- and diastereo-controlled synthesis of bis(formylmethano)[60]fullerenes and their application to the formation of [60]fullerene pearl-necklace polyimines

  摘要：

  The tether-directed method was firstly applied to the biscyclopropanation of [60]fullerene via the addition-elimination reaction of bis(sulfonium ylide)s to give bis(formylmethano)[60]fullerenes with satisfactory regio- and stereoselectivity. The equatorialbisadduct thus obtained was used for the polycondensation with an aromatic diamine to afford the corresponding pearl-necklace polyimine with satisfactorily high degree of polymerization. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.148

文献信息

• A Bodipy-bearing pillar[5]arene for mimicking photosynthesis: Multi-fluorophoric light harvesting system
  作者：Ahmed Nuri Kursunlu、Canan Baslak

  DOI：10.1016/j.tetlet.2018.04.016

  日期：2018.5

  Herein, we submitted to the original synthesis, characterization, energy transfer mechanism of the Bodipy-bearing pillar[5]arene Bodipy and its reactants by employing of infrared, H-1, B-11, C-13, F-19- NMRs, UV-vis, fluorescence spectroscopy, melting point apparatus, CHN elemental analysis and mass spectroscopy. Preliminary UV-vis, fluorescence and excitation measurements were carried out in CH2Cl2 and the results revealed an effective fluorescence resonance energy transfer (FRET) system based on the interaction of pillar[5]arene and Bodipy derivative. epsilon(max) of target molecule reached to a maximum value and it was found as 955 000 M-1 cm(-1). This fluorescent macromolecule worked well for mimicking a light harvesting system with an energy transfer efficiency up to 92%. (C) 2018 Elsevier Ltd. All rights reserved.