succinic acid monomethyl ester sodium salt | 50888-28-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: succinic acid monomethyl ester sodium salt
• 英文别名: sodium 2-carbomethoxypropionate；Sodium monomethyl succinate；sodium 4-methoxy-4-oxobutanoate；sodium;4-methoxy-4-oxobutanoate
• CAS: 50888-28-3
• 化学式: C₅H₇O₄*Na
• 分子量: 154.098
• InChiKey: KDWCFTLLFHIQHU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.31
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  succinic acid monomethyl ester sodium salt 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 sodium succinate
  参考文献：
  名称：

  Holba, Vladislav; Benko, Jan, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 11, p. 2873 - 2882

  摘要：

  DOI：
• 作为产物：
  描述：

  丁二酸酐 、 sodium methylate 以 甲醇 为溶剂， 反应 0.25h， 生成 succinic acid monomethyl ester sodium salt
  参考文献：
  名称：

  Holba, Vladislav; Benko, Jan, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 11, p. 2873 - 2882

  摘要：

  DOI：

文献信息

• DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES
  申请人：Kasai Shizuo

  公开号：US20120071489A1

  公开（公告）日：2012-03-22

  The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.

  本发明涉及一种化合物，其化学式如下所示，其中每个符号如本说明书中所定义，该化合物具有优越的降低RBP4作用，并且可用作预防或治疗由RBP4增加介导的疾病或病况的药物组合物。
• Rates and activation parameters of alkaline hydrolysis of the 2-carbomethoxypropionate ion in aqueous mixtures of dimethyl sulphoxide
  作者：Prasanta Kumar Biswas、Mihir Nath Das

  DOI：10.1039/f19868201973

  日期：——

  the 2-carbomethoxypropionate ion (R–) have been measured at 15, 25 and 35 °C in water and aqueous dimethyl sulphoxide (DMSO) mixtures of six compositions with mole fractions of DMSO varying from 0.05 to 0.40. The activation parameters have been calculated for the reaction in all these media. The thermodynamic quantities for the transfer of the reacting ion R– have been obtained from the solubilities

  在15、25和35℃下，在水和六种组成的二甲基亚砜（DMSO）混合物的水溶液中，分别测定了2-碳甲氧基丙酸根离子（R –）的碱性水解速率，其中DMSO的摩尔分数为0.05至0.40。已经在所有这些介质中计算了反应的活化参数。使用已报道的Ag +转移性质，通过不同温度下介质中银盐（AgR）的溶解度获得了反应离子R –转移的热力学量。利用这些值对于R -离子以及用于OH所报告的值-离子（另一种反应物）以及该反应的活化参数，已计算出转移态转移的热力学量。已尝试将动力学结果与热力学参数相关联，并将结果与​​中性乙酸乙酯的结果进行比较。
• Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
  申请人：Kasai Shizuo

  公开号：US08853215B2

  公开（公告）日：2014-10-07

  The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.

  本发明涉及一种化合物，其表示为式中每个符号如本说明书中所定义，该化合物具有优异的RBP4降低作用，并可作为药物组合物用于预防或治疗由RBP4增加介导的疾病或病状。
• DE2214057
  申请人：——

  公开号：——

  公开（公告）日：——
• Base catalyzed hydrolysis of Aerosol OT in Aqueous and Aquo-Dioxane media
  作者：K. Mukherjee、S. P. Moulik、D. C. Mukherjee

  DOI：10.1002/kin.550261103

  日期：1994.11

  AbstractThe OH− ion catalyzed hydrolysis of AOT and sodium mono‐methyl succinate in aqueous and aquo‐dioxane media has been studied. The second‐order rate constant for the former has been found to be nearly ten times slower than that of the latter. At AOT concentrations above CMC, the rate constants become insensitive to the concentration in the studied range of temperature, 25°C–40°C. The activation parameters for the kinetic process have been found to be reasonable, negative entropy of activation has supported a stable transition state complex. A good enthalpy‐entropy compensation of the kinetic process has been found both for AOT and sodium monomethyl succinate in aqueous and aquo‐dioxane media supporting similar nature of the transition state complexes in the hydrolytic reactions. The enthalpies of hydrolysis of AOT and the half ester of succinic acid in aqueous and aquo‐dioxane media have been also reported. © 1994 John Wiley & Sons, Inc.