2,6-di-t-butyl-4-[(dimethylphenylsilyl)methylthio]phenol | 139645-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-di-t-butyl-4-[(dimethylphenylsilyl)methylthio]phenol
• 英文别名: 2,6-Di-t-butyl-4[(dimethylphenylsilyl)methylthio]phenol；Phenol, 2,6-bis(1,1-dimethylethyl)-4-[[(dimethylphenylsilyl)methyl]thio]-；2,6-ditert-butyl-4-[[dimethyl(phenyl)silyl]methylsulfanyl]phenol
• CAS: 139645-77-5
• 化学式: C₂₃H₃₄OSSi
• 分子量: 386.674
• InChiKey: NMGQDUYLWFFFEI-UHFFFAOYSA-N

物化性质

• 沸点：
  441.1±45.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.23
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  双（3,5-二叔丁基苯-4-醇）二硫化物 在 potassium carbonate 、 锌 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 2,6-di-t-butyl-4-[(dimethylphenylsilyl)methylthio]phenol
  参考文献：
  名称：

  Antioxidant and cholesterol lowering properties of 2,6-DI-t-butyl-4-[(dimethylphenylsilyl)methyloxy]phenol and derivatives: A new class of anti-atherogenic compounds

  摘要：

  Di-t-butylphenol derivatives were synthesized and evaluated as antioxidants and cholesterol lowering agents. When evaluated in cholesterol-fed rabbits, the compounds were found to exhibit both properties. Of special interest was the finding that several of the compounds elevated HDL cholesterol levels. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00273-9

文献信息

• Method of lowering serum cholesterol levels with
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US05677291A1

  公开（公告）日：1997-10-14

  A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; Z is a thio, oxy or methylene group; A is a C.sub.1 -C.sub.4 alkylene group; and R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.

  一种通过给患有高胆固醇血症的患者施用化合物（1）的方法降低血浆胆固醇水平，其中：R.sub.1、R.sub.2、R.sub.3和R.sub.4各自独立地为C.sub.1-C.sub.6烷基基团；Z为硫、氧或亚甲基基团；A为C.sub.1-C.sub.4烷基基团；R.sub.5为C.sub.1-C.sub.6烷基或--(CH.sub.2).sub.n--(Ar)，其中n为整数0、1、2或3；Ar为苯基或萘基，未取代或经过一个到三个羟基、甲氧基、乙氧基、氯、氟或C.sub.1-C.sub.6烷基的取代。
• Method of inhibiting vascular cell adhesion molecule-1 and treating
  申请人：Hoechst Marion Rousssel, Inc.

  公开号：US05795876A1

  公开（公告）日：1998-08-18

  Methods useful for inhibiting VCAM-1 and for treating chronic inflammatory conditions in a patient in need thereof are disclosed comprising administering to the patient effective amounts of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; Z is a thio, oxy or methylene group; A is a C.sub.1 -C.sub.4 alkylene group; R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl; are disclosed.

  本文揭示了用于抑制VCAM-1并治疗患有慢性炎症症状的患者的方法，包括向患者施用化合物的有效量，其化学式为##STR1##其中R.sub.1、R.sub.2、R.sub.3和R.sub.4分别独立为C.sub.1-C.sub.6烷基基团；Z为硫、氧或亚甲基基团；A为C.sub.1-C.sub.4烷基基团；R.sub.5为C.sub.1-C.sub.6烷基或--(CH.sub.2).sub.n--(Ar)其中n为整数0、1、2或3；Ar为苯或萘，未取代或取代一个至三个亚甲基、甲氧基、乙氧基、氯、氟或C.sub.1-C.sub.6烷基的取代基。
• Antioxidant and cholesterol lowering properties of 2,6-DI-t-butyl-4-[(dimethylphenylsilyl)methyloxy]phenol and derivatives: A new class of anti-atherogenic compounds
  作者：Roger A. Parker、Roger L. Barnhart、Kim S. Chen、Michael L. Edwards、James E. Matt、Barry L. Rhinehart、Keith M. Robinson、Mark J. Vaal、Mark T. Yates

  DOI：10.1016/s0960-894x(96)00273-9

  日期：1996.7

  Di-t-butylphenol derivatives were synthesized and evaluated as antioxidants and cholesterol lowering agents. When evaluated in cholesterol-fed rabbits, the compounds were found to exhibit both properties. Of special interest was the finding that several of the compounds elevated HDL cholesterol levels. Copyright (C) 1996 Elsevier Science Ltd