N-Cbz-1-13C-L-leucine | 125069-90-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Cbz-1-13C-L-leucine
• CAS: 125069-90-1
• 化学式: C₁₄H₁₉NO₄
• 分子量: 266.298
• InChiKey: USPFMEKVPDBMCG-RHBDSMSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  19.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  75.63
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-Cbz-1-13C-L-leucine 在 三氟乙酸 作用下， 生成
  参考文献：
  名称：

  Cleavage of L-leucine-containing dipeptides by Clostridium butyricum

  摘要：

  The ability of Clostridium butyricum cultures to hydrolyze three L-leucine-containing dipeptides (Leu-Leu, Leu-Gly and Gly-Leu) in a synthetic minimal medium is demonstrated by using gas chromatography coupled with mass spectrometry. The C-13 nuclear magnetic resonance and a labeled dipeptide L-[1-C-13]Leu-Gly were used to confirm this activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00694-5
• 作为产物：
  描述：

  L-亮氨酸-1-13C 生成 N-Cbz-1-13C-L-leucine
  参考文献：
  名称：

  Fast atom bombardment mass spectrometry of carbobenzyloxy-protected amino acids and peptides

  摘要：

  AbstractThe positive fast atom bombardment (FAB) mass spectra of 15 N‐carbobenzyloxy derivatives of α‐amino acids are presented together with those of some synthetic peptides containing other widely employed protecting groups. The data obtained allow a fragmentation pattern to be established for the N‐carbobenzyloxy moiety and to obtain detailed structural information on the main fragment ions. A study of the ion current ratio vs. time pattern shows that important fragments derive from the parent protonated molecule through FAB‐induced condensed‐phase reactions.

  DOI：

  10.1002/oms.1210240405