Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.
本文提供的是包括包围核心的壳体的粒子组装体。壳体包括一种粒子稳定的随机共聚物。核心包括一种核心随机共聚物。这些粒子组装体具有仿生设计,其中包含离散
化学和
生物功能的聚合物组分被设计成自发自组装成粒子。本文还提供了具有共轭治疗剂的随机共聚物,这些治疗剂可以被酶或
水从共聚物中裂解。