| 1425313-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• CAS: 1425313-87-6
• 化学式: C₁₅H₂₀O₅
• 分子量: 280.321
• InChiKey: WMRCCXAYIVEABH-NXEZZACHSA-N

反应信息

• 作为产物：
  描述：

  三甲硅氧基-2-呋喃 、 ethyl 5,5-dimethyl-6-oxo-cyclohex-1-enecarboxylate 在 copper(II) bis(trifluoromethanesulfonate) 、 S-4,5-二氢-2-(2-((S)-4,5-二氢-4-异丙基噁唑-2-基)丙-2-基)-4-异丙基噁唑 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 2.5h， 以60%的产率得到
  参考文献：
  名称：

  Catalytic Enantioselective Vinylogous Mukaiyama–Michael Addition of 2-Silyloxyfurans to Cyclic Unsaturated Oxo Esters

  摘要：

  The copper-catalyzed asymmetric addition of 2-silyloxyfurans to cyclic unsaturated oxo esters is reported. The reaction proceeds with excellent diastereocontrol (usually dr 99:1) and modest to high enantioselectivity, depending on the nature of the ester group and the substitution of the cyclic oxo ester. We have shown that these substrates can be transformed into a variety of building blocks bearing a gamma-butenolide or gamma-lactone connected to a cycloalkane or cycoalkene moiety.

  DOI：

  10.1021/jo3020648