(3-Hydroxy-5-hydroxymethyl-phenoxy)-acetic acid tert-butyl ester | 910874-97-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Hydroxy-5-hydroxymethyl-phenoxy)-acetic acid tert-butyl ester
• 英文别名: Tert-butyl 2-[3-hydroxy-5-(hydroxymethyl)phenoxy]acetate
• CAS: 910874-97-4
• 化学式: C₁₃H₁₈O₅
• 分子量: 254.283
• InChiKey: PTFRNVKACGAPEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3-Hydroxy-5-hydroxymethyl-phenoxy)-acetic acid tert-butyl ester 在 18-冠醚-6 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 29.0h， 生成 [3-(Anthracen-9-ylmethoxy)-5-formyl-phenoxy]-acetic acid tert-butyl ester
  参考文献：
  名称：

  Selective Sensing of Metalloproteins from Nonselective Binding Using a Fluorogenic Amphiphilic Polymer

  摘要：

  Nonconjugated fluorogenic amphiphilic polymers containing an anthracene chromophore exhibit fluorescence quenching in the presence of metalloproteins, although the binding of the polymer to proteins is not selective. The reason for this difference is that the possible conformational changes that protein binding could bring about on a polymer do not affect the fluorescence properties of a pendent chromophore in nonconjugated polymers. This is in contrast to the nonspecific binding and response found with conjugated polymers to proteins.

  DOI：

  10.1021/ja063544v
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 3,5-二羟基苯甲醇 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 以43%的产率得到(3-Hydroxy-5-hydroxymethyl-phenoxy)-acetic acid tert-butyl ester
  参考文献：
  名称：

  Site-Specific Installation and Study of Electroactive Units in Every Layer of Dendrons

  摘要：

  Whereas encapsulation of functional groups at the core of dendrimers is well-understood, very little is known about their intermediate layers or even the periphery. Here we report oil a systematic investigation of every layer of dendrimers by incorporating a single ferrocene unit in well-defined locations in dendrons. Site-specific incorporation of the ferrocene unit was achieved by utilizing the dendrimer sequencing methodology. We show here that the redox potential values of ferrocene at intermediate layers were remarkably different from those at the core and the periphery. Although redox potential values were location-dependent, no significant change in the rate of heterogeneous electron transfer (k(0)) was observed with respect to locations. This was attributed to the possibility that free rotation of dendrimer nullifies the distance between the electrode and ferrocene unit. Finally, we also show that no Faradaic current was observed for the amphiphilic assemblies of these dendrons, whereas the same dendron did exhibit significant Faradaic current in nonassembling solvent environments.

  DOI：

  10.1021/jo902109u