2-(2,2,2-trichloro-1-hydroxy-ethyl)-acetoacetic acid anilide | 75456-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,2,2-trichloro-1-hydroxy-ethyl)-acetoacetic acid anilide
• 英文别名: 2-(2,2,2-Trichlor-1-hydroxy-aethyl)-acetessigsaeure-anilid
• CAS: 75456-96-1
• 化学式: C₁₂H₁₂Cl₃NO₃
• 分子量: 324.591
• InChiKey: MACZQKNMSFYSCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  水合氯醛 、 N-乙酰乙酰苯胺 生成 2-(2,2,2-trichloro-1-hydroxy-ethyl)-acetoacetic acid anilide
  参考文献：
  名称：

  Displaced intra-articular fractures of distal radius: a comparative evaluation of results following closed reduction, external fixation and open reduction with internal fixation

  摘要：

  Fractures of the distal end of the radius are common injuries and are the commonest bony injury around the wrist. Management of these fractures has remained controversial as far as modality of treatment is concerned. In this study 90 adult cases of acute displaced intra-articular fractures of the lower end of the radius were classified according to Frykman's and AO classifications after obtaining radiographs in antero-posterior and lateral planes. These were randomly treated by one of three methods: (1) closed reduction and plaster immobilisation, (2) external fixation and (3) open reduction and internal fixation, and were followed for an average of 4 yr. In the final functional assessment (Sarmiento) the results were (1) plaster 43% good and excellent, 50% fair and 7% poor, (2) external fixator 80% good and excellent, 20% fair and poor results, (3) open reduction and internal fixation 63% good and excellent, 26% fair, 11% poor. We recommend that displaced severely comminuted intra articular fractures should be treated with an external fixator. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0020-1383(99)00207-7

文献信息

• Decombe; Pretot, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954, vol. 239, p. 1502
  作者：Decombe、Pretot

  DOI：——

  日期：——