1-(benzimidazol-1-yl)ethyl acetate | 98698-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(benzimidazol-1-yl)ethyl acetate
• 英文别名: 1-(1H-benzo[d]imidazol-1-yl)ethyl acetate；1-(α-Acetoxy)-ethyl-benzimidazol；1-acetoxy-1-benzoimidazol-1-yl-ethane
• CAS: 98698-37-4
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: NJRJVKZYIJXTHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯并咪唑 、 乙酸乙烯酯 在 potassium tert-butylate 作用下， 以 乙腈 为溶剂， 反应 9.0h， 以80%的产率得到1-(benzimidazol-1-yl)ethyl acetate
  参考文献：
  名称：

  叔丁醇钾催化马尔科夫尼科夫与唑类乙酸乙烯酯的加成反应

  摘要：

  描述了一种简单有效的方法，用于叔丁醇钾催化马尔可夫尼可夫与乙酸乙烯酯的加成反应。N-杂环化合物是由简单且可商购的起始原料在温和条件下以高收率合成的。

  DOI：

  10.1016/j.cclet.2010.10.048

文献信息

• Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters
  作者：Run-tao Li、Ze-mei Ge、Song-wen Lin、Qi Sun、Tie-ming Cheng

  DOI：10.1055/s-2007-983733

  日期：2007.7

  Anhydrous potassium phosphate promoted the aza-Markovnikov addition of a variety of N-heterocycles to vinyl esters in DMF at room temperature in moderate to excellent yields.

  无水磷酸钾促进了多种含氮杂环在室温下于二甲基甲酰胺（DMF）中对乙烯基酯的马尔科夫尼科夫型加成反应，产率从中等到优秀不等。
• Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition
  作者：Sándor Nagy、Zsuzsanna Fehér、Péter Kisszékelyi、Péter Huszthy、József Kupai

  DOI：10.1039/c8nj01277f

  日期：——

  activity to catalyze the aza-Markovnikov addition reaction of N-heterocycles to vinyl esters. The synthesis of aza-Markovnikov adducts possessing valuable biological activity was thoroughly optimized. By studying the ratio of the starting materials, bases and solvents, we achieved a new and efficient protocol, which could be performed under mild conditions with a small excess of vinyl ester affording

  三种金鸡纳衍生物已显示出显着的活性，可催化N-杂环对乙烯基酯的氮杂-马尔可夫尼科夫加成反应。彻底优化了具有有价值的生物活性的氮杂-马尔可夫尼科夫加合物的合成。通过研究原料，碱和溶剂的比例，我们获得了一种新的有效方法，可以在温和条件下用少量过量的乙烯基酯进行操作，从而提供具有优异收率和高区域选择性的产品。该优化使反应的谢尔顿E因子降低了42％。此外，评估了用于催化剂再循环的膜分离以进一步提高合成的可持续性。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• NON-TOXIC CORROSION PROTECTION PIGMENTS BASED ON COBALT
  申请人：UNIVERSITY OF DAYTON

  公开号：EP1472319A1

  公开（公告）日：2004-11-03