3-nitro-N-(pyridin-3-ylmethyl)anilinne | 13175-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-nitro-N-(pyridin-3-ylmethyl)anilinne
• 英文别名: 3-nitro-N-pyridin-3-ylmethyl-aniline；3-(3-Nitrophenylaminomethyl)pyridine；3-nitro-N-(pyridin-3-ylmethyl)aniline
• CAS: 13175-12-7
• 化学式: C₁₂H₁₁N₃O₂
• mdl: MFCD12412732
• 分子量: 229.238
• InChiKey: OLNPCHBSCLFHLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-nitro-N-(pyridin-3-ylmethyl)anilinne 在 一水合肼 作用下， 以 水 为溶剂， 以84%的产率得到N-(pyridin-3-ylmethyl)benzene-1,3-diamine
  参考文献：
  名称：

  Reductive transformations of Schiff bases in the synthesis of functionally substituted heteroaromatic amines

  摘要：

  Schiff bases synthesized by condensation of 5- and 6-aminoquinolines, 5-amino-2-methylquinoline, nitroanilines, and pyrimidinylaminoanilines with substituted benzaldehydes and pyridinecarbaldehydes were reduced with sodium tetrahydridoborate in acetic acid to obtain the corresponding N-aryl(hetaryl)benzylamines, N-(pyridylmethyl)anilines, and N-(1,2,3,4-tetrahydroquinolyl)benzylamine derivatives. The reduction of arylhetarylimines with hydrazine hydrate in the presence of Raney nickel involved only the azomethine C=N bond, while the nitrogen-containing heteroaromatic ring remained intact. Under analogous conditions, nitrosubstituted Schiff bases and benzyl- and pyridylmethylamines were converted into previously unknown N-(aminobenzyl)quinolinamines and aryl(pyridyl)methyl-substituted phenylenediamines.

  DOI：

  10.1134/s1070428009070148
• 作为产物：
  描述：

  3-nitro-N-(pyridin-3-ylmethylidene)anilinne 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 苯 为溶剂， 以80%的产率得到3-nitro-N-(pyridin-3-ylmethyl)anilinne
  参考文献：
  名称：

  Reductive transformations of Schiff bases in the synthesis of functionally substituted heteroaromatic amines

  摘要：

  Schiff bases synthesized by condensation of 5- and 6-aminoquinolines, 5-amino-2-methylquinoline, nitroanilines, and pyrimidinylaminoanilines with substituted benzaldehydes and pyridinecarbaldehydes were reduced with sodium tetrahydridoborate in acetic acid to obtain the corresponding N-aryl(hetaryl)benzylamines, N-(pyridylmethyl)anilines, and N-(1,2,3,4-tetrahydroquinolyl)benzylamine derivatives. The reduction of arylhetarylimines with hydrazine hydrate in the presence of Raney nickel involved only the azomethine C=N bond, while the nitrogen-containing heteroaromatic ring remained intact. Under analogous conditions, nitrosubstituted Schiff bases and benzyl- and pyridylmethylamines were converted into previously unknown N-(aminobenzyl)quinolinamines and aryl(pyridyl)methyl-substituted phenylenediamines.

  DOI：

  10.1134/s1070428009070148

文献信息

• Agriculturally useful sulfonamides
  申请人：Eli Lilly and Company

  公开号：US04874775A1

  公开（公告）日：1989-10-17

  A series of novel N-pyrinidyl- and pyrimidinyl sulfonamides are useful as fungicides and herbicides particularly for the protection of plants from phytopathogens.

  一系列新型的N-吡啶基和嘧啶基磺酰胺可用作杀菌剂和除草剂，特别适用于保护植物免受植物病原体的侵害。
• Agriculturally-useful sulfonamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0206581A2

  公开（公告）日：1986-12-30

  @ A series of novel N-pyridinyl- and pyrinidinyl sulfonamides are useful as fungicides and herbicides. These compounds are particularly useful for the protection of plants from phytopathogens.

  一系列新型 N-吡啶基和吡啶基磺酰胺可用作杀真菌剂和除草剂。 这些化合物尤其有助于保护植物免受植物病原体的侵害。
• US4874775A
  申请人：——

  公开号：US4874775A

  公开（公告）日：1989-10-17