3-hydrazinocarbonyl-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide | 959756-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-hydrazinocarbonyl-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide
• 英文别名: 3-hydrazinocarbonyl-N-(4-oxo-3,4-dihydro-quinazolin-3-yl)propanamide；4-hydrazinyl-4-oxo-N-(4-oxoquinazolin-3-yl)butanamide
• CAS: 959756-92-4
• 化学式: C₁₂H₁₃N₅O₃
• 分子量: 275.267
• InChiKey: OKFSTMBZTDAMOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-hydrazinocarbonyl-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide 、 丙酮 以 N,N-二甲基甲酰胺 为溶剂， 以55%的产率得到3-(isopropylidenehydrazinocarbonyl)-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide
  参考文献：
  名称：

  Synthesis of N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinimide and N-(4-oxoquinazolin-3-yl)succinamic acid derivatives based thereon

  摘要：

  The reaction of anthranilic acid hydrazide with diethyl oxalate under microwave irradiation was accompanied by decarboxylation with formation of 3-amino-3,4-dihydroquinazolin-4-one, and acylation of the latter with succinic anhydride gave N-(4-oxo-3,4-dihydroquinazolin-3-yl)siccinimide which was converted into various N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinamic acid derivatives.

  DOI：

  10.1134/s1070428007040215
• 作为产物：
  描述：

  2-氨基亚苯基肼 在 一水合肼 作用下， 以 1,4-二氧六环 、 溶剂黄146 为溶剂， 反应 0.79h， 生成 3-hydrazinocarbonyl-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide
  参考文献：
  名称：

  Synthesis of N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinimide and N-(4-oxoquinazolin-3-yl)succinamic acid derivatives based thereon

  摘要：

  The reaction of anthranilic acid hydrazide with diethyl oxalate under microwave irradiation was accompanied by decarboxylation with formation of 3-amino-3,4-dihydroquinazolin-4-one, and acylation of the latter with succinic anhydride gave N-(4-oxo-3,4-dihydroquinazolin-3-yl)siccinimide which was converted into various N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinamic acid derivatives.

  DOI：

  10.1134/s1070428007040215