1,1'-Biadamantan-3,3'-dicarbonsaeure | 15417-14-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,1'-Biadamantan-3,3'-dicarbonsaeure
• 英文别名: 3,3'-Dicarboxy-1,1'-biadamantan；1,1'-Diadamantyl-3,3'-dicarbonsaeure；1,1'-Diadamantan-3,3'-dicarbonsaeure；1,1'-Bi(tricyclo[3.3.1.1~3,7~]decane)-3,3'-dicarboxylic acid；3-(3-carboxy-1-adamantyl)adamantane-1-carboxylic acid
• CAS: 15417-14-8
• 化学式: C₂₂H₃₀O₄
• 分子量: 358.478
• InChiKey: CCHZMJCCPSQDSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲酸 、 1,1'-Biadamantan-3,3'-dicarbonsaeure 在 硫酸 、 硝酸 作用下， 反应 4.0h， 以76%的产率得到1.1'-Biadamantyl-3.3'.5.5'-tetracarbonsaeure
  参考文献：
  名称：

  Butenko, L. N.; Protopopov, P. A.; Derbisher, V. E., Synthetic Communications, 1984, vol. 14, # 2, p. 113 - 120

  摘要：

  DOI：
• 作为产物：
  描述：

  甲酸 、 1,1’-双金刚烷 在 硫酸 、 三氧化硫 作用下， 反应 0.08h， 生成 1,1'-Biadamantan-3,3'-dicarbonsaeure
  参考文献：
  名称：

  [EN] 1,1'-DIADAMANTYL CARBOXYLIC ACIDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE
  [FR] ACIDES 1,1'-DIADAMANTYL CARBOXYLIQUES, MÉDICAMENTS CONTENANT DE TELS COMPOSÉS ET APPLICATION ASSOCIÉE

  摘要：

  本发明涉及由式（I）定义的化合物，其中基团R如权利要求1中所定义，具有有价值的药理活性。特别是这些化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可以受到该酶抑制影响的疾病，如代谢性疾病。

  公开号：

  WO2010010174A1

文献信息

• HNF4-alpha ANTAGONIST AND USE THEREOF
  申请人：NATIONAL CANCER CENTER

  公开号：US20160193238A1

  公开（公告）日：2016-07-07

  Provided is a hepatocyte nuclear factor 4 alpha (HNF4-α) antagonist and a use thereof. The HNF4-α antagonist selected in the present invention was confirmed to specifically bind to the ligand binding domain of HNF4-α, thereby inhibiting the activity of HNF4-α. The HNF4-α antagonist of the present invention can significantly reduce the expression of Wnt5a in a specific manner compared to that of the conventional known HNF4-α antagonists, and can also inhibit the growth of gastric cancer cells. Therefore, the HNF4-α antagonist of the present invention can not only be used as a pharmaceutical composition or a health functional food for preventing and treating cancer but can also be applied to a composition for treating or preventing diseases occurring due to the overexpression of HNF4-α.

  提供了一种肝细胞核因子4α（HNF4-α）拮抗剂及其用途。本发明选择的HNF4-α拮抗剂被确认能够特异性结合到HNF4-α的配体结合域，从而抑制HNF4-α的活性。与传统已知的HNF4-α拮抗剂相比，本发明的HNF4-α拮抗剂可以显著特异性地降低Wnt5a的表达，并且还能抑制胃癌细胞的生长。因此，本发明的HNF4-α拮抗剂不仅可以用作预防和治疗癌症的药物组合物或健康功能性食品，还可以应用于治疗或预防由于HNF4-α过度表达而导致的疾病的组合物。
• Benzoxazole Resin Precursor, Polybenzoxazole Resin, Resin Film And Semiconductor Device
  申请人：Enoki Takashi

  公开号：US20080206548A1

  公开（公告）日：2008-08-28

  A benzoxazole resin precursor comprising a first repeating unit which is obtained by the reaction of a bisaminophenol compound and a dicarboxylic acid compound, at least one of which has the diamondoid structure; a benzoxazole resin precursor further comprising a second repeating unit which is obtained by the reaction of a bisaminophenol compound having no diamondoid structure and a dicarboxylic acid compound having no diamondoid structure; a polybenzoxazole resin obtained by the ring-closing reaction with dehydration of the above benzoxazole resin precursor; a resin film constituted with the benzoxazole resin precursor or the polybenzoxazole resin. A polybenzoxazole resin and a resin film having excellent heat resistance and a small permittivity and a semiconductor device using the resin film can be obtained from the benzoxazole resin precursor.

  一种苯并噁唑树脂前体，包括第一重复单元，该单元由双氨基酚化合物和二羧酸化合物反应得到，其中至少一个具有金刚烷结构；一种苯并噁唑树脂前体，进一步包括第二重复单元，该单元由不具有金刚烷结构的双氨基酚化合物和不具有金刚烷结构的二羧酸化合物反应得到；通过上述苯并噁唑树脂前体的环合反应和脱水反应得到的聚苯并噁唑树脂；由苯并噁唑树脂前体或聚苯并噁唑树脂构成的树脂膜。可以从苯并噁唑树脂前体中获得具有优异耐热性和小介电常数的聚苯并噁唑树脂和树脂膜，以及使用树脂膜的半导体器件。
• 1,1'-Diadamantyl carboxylic acids, medicaments containing such compounds and their use
  申请人：Eckhardt Matthias

  公开号：US20110269736A1

  公开（公告）日：2011-11-03

  The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases.

  本发明涉及具有有价值的药理活性的公式（I）所定义的化合物，其中R基团如权利要求1所定义。特别地，这些化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可以通过抑制该酶而受到影响的疾病，例如代谢性疾病。
• Resin Composition, Varnish, Resin Film and Semiconductor Device
  申请人：Enoki Takashi

  公开号：US20090214860A1

  公开（公告）日：2009-08-27

  Disclosed is a resin composition comprising a benzoxazole resin precursor having a first repeating unit obtained by reacting a bisaminophenol compound and a dicarboxylic acid compound, and a cross-linking agent wherein at least one of the bisaminophenol compound and the dicarboxylic acid compound has a diamondoid structure. The benzoxazole resin precursor further comprises a second repeating unit obtained by reacting a bisaminophenol compound not having a diamondoid structure and a dicarboxylic acid compound not having a diamondoid structure. Also disclosed is a resin film comprising the resin composition.

  本发明公开了一种树脂组合物，包括一种苯并噁唑树脂前体，其具有通过反应双氨基酚化合物和二羧酸化合物得到的第一重复单元，以及交联剂，其中双氨基酚化合物和/或二羧酸化合物中至少有一个具有金刚烷结构。苯并噁唑树脂前体还包括通过反应不具有金刚烷结构的双氨基酚化合物和不具有金刚烷结构的二羧酸化合物得到的第二重复单元。此外，本发明还公开了一种包括该树脂组合物的树脂膜。
• Resist composition and method for manufacturing semiconductor device using the resist composition
  申请人：Semiconductor Leading Edge Technologies, Inc.

  公开号：EP1179749A1

  公开（公告）日：2002-02-13

  A resist composition comprises: at least one type of a first compound having two or more intramolecular adamantyl structures represented by the chemical formula 1 below; a base resin; and a second compound which generates an acid by active beam irradiation. wherein X is -(OCO)m-(CH2)n-(COO)m-, where m = 0 or 1 and n = 0, 1, 2 or 3 provided when n = 0, m = 0; and Y and Z are H, OH, F, Cl, Br, R or COOR, where Y may be Z, or Y and Z may be introduced in a single adamantyl structure and R represents a straight or branched alkyl group having 1 to 8 carbon atoms.

  抗蚀剂组合物包括：至少一种具有两个或两个以上分子内金刚烷基结构的第一种化合物（如下化学式 1 所示）；碱树脂；以及通过活性光束照射产生酸的第二种化合物。 其中 X 是-(OCO)m-(CH2)n-(COO)m-，其中 m = 0 或 1，n = 0、1、2 或 3，当 n = 0 时，m = 0；以及 Y 和 Z 是 H、OH、F、Cl、Br、R 或 COOR，其中 Y 可以是 Z，或 Y 和 Z 可以在单个金刚烷基结构中引入，R 代表具有 1 至 8 个碳原子的直链或支链烷基。