methyl (2S)-1-(2-methylpyridine-3-carbonyl)pyrrolidine-2-carboxylate | 478357-76-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-1-(2-methylpyridine-3-carbonyl)pyrrolidine-2-carboxylate
• CAS: 478357-76-5
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: SPAWSYBMKOEWTK-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  59.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (2S)-1-(2-methylpyridine-3-carbonyl)pyrrolidine-2-carboxylate 、 碘甲烷 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Diastereoselective heterogeneous catalytic hydrogenation of 2-methyl nicotinic acid using pyroglutamate chiral auxiliary

  摘要：

  The diastereoselective hydrogenation of 2-methyl nicotinic acid covalently bound to proline ester or pyroglutamic ester over supported metallic catalyst yielded moderate diastereoselectivity (26%). The hydrogenation of the corresponding pyridinium salt was studied and similar de's were achieved. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01794-5
• 作为产物：
  描述：

  2-甲基烟酸 、 L-脯氨酸甲酯 在 氯化亚砜 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 15.0h， 以92%的产率得到methyl (2S)-1-(2-methylpyridine-3-carbonyl)pyrrolidine-2-carboxylate
  参考文献：
  名称：

  Diastereoselective heterogeneous catalytic hydrogenation of 2-methyl nicotinic acid using pyroglutamate chiral auxiliary

  摘要：

  The diastereoselective hydrogenation of 2-methyl nicotinic acid covalently bound to proline ester or pyroglutamic ester over supported metallic catalyst yielded moderate diastereoselectivity (26%). The hydrogenation of the corresponding pyridinium salt was studied and similar de's were achieved. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01794-5

文献信息

• Diastereoselective heterogeneous catalytic hydrogenation of 2-methyl nicotinic acid using pyroglutamate chiral auxiliary
  作者：Najiba Douja、Raluca Malacea、Mircea Banciu、Michèle Besson、Catherine Pinel

  DOI：10.1016/s0040-4039(03)01794-5

  日期：2003.9

  The diastereoselective hydrogenation of 2-methyl nicotinic acid covalently bound to proline ester or pyroglutamic ester over supported metallic catalyst yielded moderate diastereoselectivity (26%). The hydrogenation of the corresponding pyridinium salt was studied and similar de's were achieved. (C) 2003 Elsevier Ltd. All rights reserved.