| 1189347-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1189347-67-8
• 化学式: C₆₀H₄₉N₉O₁₉
• 分子量: 1200.1
• InChiKey: GJIJMHQTMOOXLK-QLZWYOTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  88.0
• 可旋转键数：
  2.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  439.19
• 氢给体数：
  14.0
• 氢受体数：
  20.0

反应信息

• 作为反应物：
  描述：

  n-decyl propargyl ether 、 在 copper(l) iodide 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以64%的产率得到
  参考文献：
  名称：

  Diazo Transfer−Click Reaction Route to New, Lipophilic Teicoplanin and Ristocetin Aglycon Derivatives with High Antibacterial and Anti-influenza Virus Activity: An Aggregation and Receptor Binding Study

  摘要：

  Semisynthetic, lipophilic ristocetin and teicoplanin derivatives were prepared starting from ristocetin aglycon and teicoplanin psi-aglycon (N-acetyl-D-glucosaminyl aglycoteicoplanin). The terminal amino functions of the aglycons were converted into azido form by triflic azide. Copper catalyzed 1,3-dipolar cycloaddition reaction with lipophilic alkynes resulted in the title compounds. Two of the teicoplanin derivatives showed very good MIC and MBC values against various Gram-positive bacteria, including vanA enterococci. The aggregation and interaction of a n-decyl derivative with bacterial cell wall components Was Studied. One of the lipophilic ristocetin derivatives displayed favorable anti-influenza virus activity.

  DOI：

  10.1021/jm900950d
• 作为产物：
  描述：

  ristocetin aglycone 在 triflic azide 、 copper(II) sulfate 、 三乙胺 作用下， 以 吡啶 、 水 为溶剂， 生成
  参考文献：
  名称：

  Diazo Transfer−Click Reaction Route to New, Lipophilic Teicoplanin and Ristocetin Aglycon Derivatives with High Antibacterial and Anti-influenza Virus Activity: An Aggregation and Receptor Binding Study

  摘要：

  Semisynthetic, lipophilic ristocetin and teicoplanin derivatives were prepared starting from ristocetin aglycon and teicoplanin psi-aglycon (N-acetyl-D-glucosaminyl aglycoteicoplanin). The terminal amino functions of the aglycons were converted into azido form by triflic azide. Copper catalyzed 1,3-dipolar cycloaddition reaction with lipophilic alkynes resulted in the title compounds. Two of the teicoplanin derivatives showed very good MIC and MBC values against various Gram-positive bacteria, including vanA enterococci. The aggregation and interaction of a n-decyl derivative with bacterial cell wall components Was Studied. One of the lipophilic ristocetin derivatives displayed favorable anti-influenza virus activity.

  DOI：

  10.1021/jm900950d

文献信息

• Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity
  作者：Gábor Pintér、Ilona Bereczki、Gyula Batta、Réka Ötvös、Ferenc Sztaricskai、Erzsébet Rőth、Eszter Ostorházi、Ferenc Rozgonyi、Lieve Naesens、Mariann Szarvas、Zoltán Boda、Pál Herczegh

  DOI：10.1016/j.bmcl.2010.03.080

  日期：2010.5

  New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against Gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus. (C) 2010 Elsevier Ltd. All rights reserved.